Myocardial fibrosis in primary aldosteronism
ObjectiveWe investigated myocardial fibrosis in relation to clinical and biochemical characteristics and the metabolomics in patients with primary aldosteronism.MethodsOur study included 54 patients with primary aldosteronism. We performed cardiac magnetic resonance to evaluate focal replacement myo...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1567876/full |
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| author | Yi-Lin Chen Chi-Hua Chen Xiao-Fei Ye Jian-Zhong Xu Li-Min Zhu Ting-Yan Xu Yan Li Ji-Guang Wang |
| author_facet | Yi-Lin Chen Chi-Hua Chen Xiao-Fei Ye Jian-Zhong Xu Li-Min Zhu Ting-Yan Xu Yan Li Ji-Guang Wang |
| author_sort | Yi-Lin Chen |
| collection | DOAJ |
| description | ObjectiveWe investigated myocardial fibrosis in relation to clinical and biochemical characteristics and the metabolomics in patients with primary aldosteronism.MethodsOur study included 54 patients with primary aldosteronism. We performed cardiac magnetic resonance to evaluate focal replacement myocardial fibrosis defined as late gadolinium enhancement (LGE) and diffuse interstitial fibrosis as assessed by extracellular volume (ECV) with T1 mapping. We collected information on demographics and data of clinical biomarkers, and performed echocardiography and metabolomic analysis.ResultsPatients with LGE (n=30), compared with those without LGE (n=24), had a longer duration of hypertension, higher 24-hour, daytime and nighttime systolic blood pressure, left ventricular mass index, and plasma NT-proBNP (P<0.001). However, they had comparable T1 mapping measurements including ECV. LGE significantly (P ≤ 0.007) and positively correlated with the duration of hypertension, ambulatory systolic blood pressure and LVMI, while ECV and native T1 were significantly (P ≤ 0.027) and inversely associated with plasma renin activity and positively associated with aldosterone-to-renin ratio. Besides, both LGE and ECV significantly (P ≤ 0.030) and positively correlated with NT-proBNP. Non-targeted metabolomic analysis showed that the amino-acid metabolism, especially the L-glutamate metabolism, significantly differed between patients with LGE and those without LGE and correlated with blood pressure and echocardiographic measurements.ConclusionIn patients with primary aldosteronism, focal replacement fibrosis was associated with cardiac afterload factors such as blood pressure, while diffuse interstitial fibrosis was associated with hyperaldosteronism. The amino-acid metabolism, especially the L-glutamate metabolism, might be involved in the process of myocardial fibrosis. |
| format | Article |
| id | doaj-art-1745fcb3ba4e4ef1967b63feb72f7f2e |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-1745fcb3ba4e4ef1967b63feb72f7f2e2025-08-20T03:11:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-05-011610.3389/fendo.2025.15678761567876Myocardial fibrosis in primary aldosteronismYi-Lin Chen0Chi-Hua Chen1Xiao-Fei Ye2Jian-Zhong Xu3Li-Min Zhu4Ting-Yan Xu5Yan Li6Ji-Guang Wang7Department of Cardiovascular Medicine, National Research Center for Translational Medicine, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, National Research Center for Translational Medicine, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, National Research Center for Translational Medicine, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, National Research Center for Translational Medicine, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, National Research Center for Translational Medicine, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Cardiovascular Medicine, National Research Center for Translational Medicine, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaObjectiveWe investigated myocardial fibrosis in relation to clinical and biochemical characteristics and the metabolomics in patients with primary aldosteronism.MethodsOur study included 54 patients with primary aldosteronism. We performed cardiac magnetic resonance to evaluate focal replacement myocardial fibrosis defined as late gadolinium enhancement (LGE) and diffuse interstitial fibrosis as assessed by extracellular volume (ECV) with T1 mapping. We collected information on demographics and data of clinical biomarkers, and performed echocardiography and metabolomic analysis.ResultsPatients with LGE (n=30), compared with those without LGE (n=24), had a longer duration of hypertension, higher 24-hour, daytime and nighttime systolic blood pressure, left ventricular mass index, and plasma NT-proBNP (P<0.001). However, they had comparable T1 mapping measurements including ECV. LGE significantly (P ≤ 0.007) and positively correlated with the duration of hypertension, ambulatory systolic blood pressure and LVMI, while ECV and native T1 were significantly (P ≤ 0.027) and inversely associated with plasma renin activity and positively associated with aldosterone-to-renin ratio. Besides, both LGE and ECV significantly (P ≤ 0.030) and positively correlated with NT-proBNP. Non-targeted metabolomic analysis showed that the amino-acid metabolism, especially the L-glutamate metabolism, significantly differed between patients with LGE and those without LGE and correlated with blood pressure and echocardiographic measurements.ConclusionIn patients with primary aldosteronism, focal replacement fibrosis was associated with cardiac afterload factors such as blood pressure, while diffuse interstitial fibrosis was associated with hyperaldosteronism. The amino-acid metabolism, especially the L-glutamate metabolism, might be involved in the process of myocardial fibrosis.https://www.frontiersin.org/articles/10.3389/fendo.2025.1567876/fullprimary aldosteronismmyocardial fibrosislate gadolinium enhancementextracellular volumemetabolomic analysis |
| spellingShingle | Yi-Lin Chen Chi-Hua Chen Xiao-Fei Ye Jian-Zhong Xu Li-Min Zhu Ting-Yan Xu Yan Li Ji-Guang Wang Myocardial fibrosis in primary aldosteronism Frontiers in Endocrinology primary aldosteronism myocardial fibrosis late gadolinium enhancement extracellular volume metabolomic analysis |
| title | Myocardial fibrosis in primary aldosteronism |
| title_full | Myocardial fibrosis in primary aldosteronism |
| title_fullStr | Myocardial fibrosis in primary aldosteronism |
| title_full_unstemmed | Myocardial fibrosis in primary aldosteronism |
| title_short | Myocardial fibrosis in primary aldosteronism |
| title_sort | myocardial fibrosis in primary aldosteronism |
| topic | primary aldosteronism myocardial fibrosis late gadolinium enhancement extracellular volume metabolomic analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1567876/full |
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