HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses

HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses

Abstract Syphilis, caused by Treponema pallidum (Tp), represents a significant public health challenge. The clinical manifestations of syphilis are attributed to local inflammatory responses induced by Tp, notably monocyte infiltration into local lesions and the secretion of inflammatory cytokines....

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Bibliographic Details
Main Authors: Shun Xiong, Zhaoping Liu, Jiangchen Yao, Shaobin Huang, Xuan Ding, Han Yu, Ting Lin, Xiaohong Zhang, Feijun Zhao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Treponema pallidum
Monocyte
Inflammatory
Glycolysis
HIF-1α
Online Access:https://doi.org/10.1186/s12964-025-02211-1
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