Ferroptosis in thyroid cancer: mechanisms, current status, and treatment
Thyroid cancer (TC) represents the most prevalent malignancy within the endocrine system. In recent years, there has been a marked global increase in the incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into the pathogenesis of TC have identified a...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1495617/full |
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| author | Wenzhi Tian Wenzhi Tian Xi Su Chenchen Hu Dong Chen Peng Li |
| author_facet | Wenzhi Tian Wenzhi Tian Xi Su Chenchen Hu Dong Chen Peng Li |
| author_sort | Wenzhi Tian |
| collection | DOAJ |
| description | Thyroid cancer (TC) represents the most prevalent malignancy within the endocrine system. In recent years, there has been a marked global increase in the incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into the pathogenesis of TC have identified a significant association with ferroptosis, a newly characterized form of cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is characterized by the accumulation of lipid peroxides and reactive oxygen species, culminating in cellular damage and death.Recent research has elucidated a connection between ferroptosis and the initiation, progression, and treatment of thyroid cancer. These findings underscore the significance of ferroptosis in thyroid cancer and offer valuable insights into the development of novel therapeutic strategies and precise predictive markers. The unique mechanisms of ferroptosis present opportunities for targeting treatment-resistant thyroid cancers. Consequently, the regulation of ferroptosis may emerge as a novel therapeutic target, potentially addressing the limitations of current treatments. Moreover, elucidating the molecular mechanisms underpinning ferroptosis in thyroid cancer may facilitate the identification of novel biomarkers for early detection and prognostication. This review endeavors to synthesize the extant knowledge regarding the role of ferroptosis in thyroid cancer, examine potential therapeutic implications, and propose future research trajectories to enhance the understanding and clinical application of ferroptosis. |
| format | Article |
| id | doaj-art-173ee8a0ca1a4b94a4a3f49c8b5fb1cd |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-173ee8a0ca1a4b94a4a3f49c8b5fb1cd2025-01-23T05:10:26ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14956171495617Ferroptosis in thyroid cancer: mechanisms, current status, and treatmentWenzhi Tian0Wenzhi Tian1Xi Su2Chenchen Hu3Dong Chen4Peng Li5Department of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Peking University-The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong, ChinaShenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, ChinaDepartment of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Peking University-The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong, ChinaDepartment of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Peking University-The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong, ChinaDepartment of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Peking University-The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong, ChinaDepartment of Thyroid and Breast Surgery, Peking University Shenzhen Hospital, Peking University-The Hong Kong University of Science and Technology Medical Centre, Shenzhen, Guangdong, ChinaThyroid cancer (TC) represents the most prevalent malignancy within the endocrine system. In recent years, there has been a marked global increase in the incidence of thyroid cancer, garnering substantial scientific interest. Comprehensive investigations into the pathogenesis of TC have identified a significant association with ferroptosis, a newly characterized form of cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is characterized by the accumulation of lipid peroxides and reactive oxygen species, culminating in cellular damage and death.Recent research has elucidated a connection between ferroptosis and the initiation, progression, and treatment of thyroid cancer. These findings underscore the significance of ferroptosis in thyroid cancer and offer valuable insights into the development of novel therapeutic strategies and precise predictive markers. The unique mechanisms of ferroptosis present opportunities for targeting treatment-resistant thyroid cancers. Consequently, the regulation of ferroptosis may emerge as a novel therapeutic target, potentially addressing the limitations of current treatments. Moreover, elucidating the molecular mechanisms underpinning ferroptosis in thyroid cancer may facilitate the identification of novel biomarkers for early detection and prognostication. This review endeavors to synthesize the extant knowledge regarding the role of ferroptosis in thyroid cancer, examine potential therapeutic implications, and propose future research trajectories to enhance the understanding and clinical application of ferroptosis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1495617/fullthyroid cancerferroptosismechanismstherapeutic targetsreactive oxygen species |
| spellingShingle | Wenzhi Tian Wenzhi Tian Xi Su Chenchen Hu Dong Chen Peng Li Ferroptosis in thyroid cancer: mechanisms, current status, and treatment Frontiers in Oncology thyroid cancer ferroptosis mechanisms therapeutic targets reactive oxygen species |
| title | Ferroptosis in thyroid cancer: mechanisms, current status, and treatment |
| title_full | Ferroptosis in thyroid cancer: mechanisms, current status, and treatment |
| title_fullStr | Ferroptosis in thyroid cancer: mechanisms, current status, and treatment |
| title_full_unstemmed | Ferroptosis in thyroid cancer: mechanisms, current status, and treatment |
| title_short | Ferroptosis in thyroid cancer: mechanisms, current status, and treatment |
| title_sort | ferroptosis in thyroid cancer mechanisms current status and treatment |
| topic | thyroid cancer ferroptosis mechanisms therapeutic targets reactive oxygen species |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1495617/full |
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