ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY
Aim. To evaluate the effect of imidasoline agonist, rilmenidine (Albarel), on 24-hour blood pressure (BP) profile and autonomic regulation of cardiovascular system in young patients with arterial hypertension (HT) and exogenous constitutional obesity (ECO).Material and methods. The study included 80...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-12-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/410 |
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| author | N. N. Nikitina A. G. Avtandilov K. R. Petrosyan S. L. Petrosov |
| author_facet | N. N. Nikitina A. G. Avtandilov K. R. Petrosyan S. L. Petrosov |
| author_sort | N. N. Nikitina |
| collection | DOAJ |
| description | Aim. To evaluate the effect of imidasoline agonist, rilmenidine (Albarel), on 24-hour blood pressure (BP) profile and autonomic regulation of cardiovascular system in young patients with arterial hypertension (HT) and exogenous constitutional obesity (ECO).Material and methods. The study included 80 men aged 18-32 ( average age 20,5 years), including 34 patients with HT and normal body weight, 36 patients with HT and ECO, 10 healthy men as a control group. All hypertensive patients were treated with rilmenidine 1-2 mg daily during 12 weeks. BP 24-hour profile and heart rate variability (HRV) were estimated before and after therapy.Results. Rilmenidine monotherapy resulted in significant reduction in average 24-hour, day-time and night-time BP as well as indices of BP loading in both groups. Indices of HRV proved the initial sympathetic overdrive among hypertensive patients especially among those with ECO. This sympathetic overdrive significantly reduced after 12 weeks of therapy.Conclusion. Rilmenidine effectively controls BP and reduces sympathetic system overdrive in young hypertensive patients with ECO. |
| format | Article |
| id | doaj-art-173dd80864364bea9e6a970c8ec3db81 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-173dd80864364bea9e6a970c8ec3db812025-08-23T10:00:19ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-12-0132434710.20996/1819-6446-2007-3-2-43-47410ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPYN. N. Nikitina0A. G. Avtandilov1K. R. Petrosyan2S. L. Petrosov3Russian Medical Academy of postgraduate education, MoscowRussian Medical Academy of postgraduate education, MoscowRussian Medical Academy of postgraduate education, MoscowRussian Medical Academy of postgraduate education, MoscowAim. To evaluate the effect of imidasoline agonist, rilmenidine (Albarel), on 24-hour blood pressure (BP) profile and autonomic regulation of cardiovascular system in young patients with arterial hypertension (HT) and exogenous constitutional obesity (ECO).Material and methods. The study included 80 men aged 18-32 ( average age 20,5 years), including 34 patients with HT and normal body weight, 36 patients with HT and ECO, 10 healthy men as a control group. All hypertensive patients were treated with rilmenidine 1-2 mg daily during 12 weeks. BP 24-hour profile and heart rate variability (HRV) were estimated before and after therapy.Results. Rilmenidine monotherapy resulted in significant reduction in average 24-hour, day-time and night-time BP as well as indices of BP loading in both groups. Indices of HRV proved the initial sympathetic overdrive among hypertensive patients especially among those with ECO. This sympathetic overdrive significantly reduced after 12 weeks of therapy.Conclusion. Rilmenidine effectively controls BP and reduces sympathetic system overdrive in young hypertensive patients with ECO.https://www.rpcardio.online/jour/article/view/410arterial hypertensionyoung ageobesityambulatory blood pressure monitoringheart rate variabilityrilmenidine |
| spellingShingle | N. N. Nikitina A. G. Avtandilov K. R. Petrosyan S. L. Petrosov ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY Рациональная фармакотерапия в кардиологии arterial hypertension young age obesity ambulatory blood pressure monitoring heart rate variability rilmenidine |
| title | ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY |
| title_full | ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY |
| title_fullStr | ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY |
| title_full_unstemmed | ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY |
| title_short | ARTERIAL HYPERTENSION IN YOUNG PEOPLE: EFFICACY OF SYMPATHOLYTIC THERAPY |
| title_sort | arterial hypertension in young people efficacy of sympatholytic therapy |
| topic | arterial hypertension young age obesity ambulatory blood pressure monitoring heart rate variability rilmenidine |
| url | https://www.rpcardio.online/jour/article/view/410 |
| work_keys_str_mv | AT nnnikitina arterialhypertensioninyoungpeopleefficacyofsympatholytictherapy AT agavtandilov arterialhypertensioninyoungpeopleefficacyofsympatholytictherapy AT krpetrosyan arterialhypertensioninyoungpeopleefficacyofsympatholytictherapy AT slpetrosov arterialhypertensioninyoungpeopleefficacyofsympatholytictherapy |