Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology
Abstract Research on pancreatic cancer has transformed with the advent of organoid technology, providing a better platform that closely mimics cancer biology in vivo. This review highlights the critical advancements facilitated by pancreatic organoid models in understanding disease progression, eval...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-024-01378-w |
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| _version_ | 1825197566657036288 |
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| author | Jihao Xu Minh Duc Pham Vincenzo Corbo Mariano Ponz-Sarvise Tobiloba Oni Daniel Öhlund Chang-Il Hwang |
| author_facet | Jihao Xu Minh Duc Pham Vincenzo Corbo Mariano Ponz-Sarvise Tobiloba Oni Daniel Öhlund Chang-Il Hwang |
| author_sort | Jihao Xu |
| collection | DOAJ |
| description | Abstract Research on pancreatic cancer has transformed with the advent of organoid technology, providing a better platform that closely mimics cancer biology in vivo. This review highlights the critical advancements facilitated by pancreatic organoid models in understanding disease progression, evaluating therapeutic responses, and identifying biomarkers. These three-dimensional cultures enable the proper recapitulation of the cellular architecture and genetic makeup of the original tumors, providing insights into the complex molecular and cellular dynamics at various stages of pancreatic ductal adenocarcinoma (PDAC). We explore the applications of pancreatic organoids in dissecting the tumor microenvironment (TME); elucidating cancer progression, metastasis, and drug resistance mechanisms; and personalizing therapeutic strategies. By overcoming the limitations of traditional 2D cultures and animal models, the use of pancreatic organoids has significantly accelerated translational research, which is promising for improving diagnostic and therapeutic approaches in clinical settings, ultimately aiming to improve the outcomes of patients with pancreatic cancer. |
| format | Article |
| id | doaj-art-173c2de27c0940f5a293272dfec29641 |
| institution | Kabale University |
| issn | 2092-6413 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj-art-173c2de27c0940f5a293272dfec296412025-02-09T12:14:09ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132025-01-01571505810.1038/s12276-024-01378-wAdvancing pancreatic cancer research and therapeutics: the transformative role of organoid technologyJihao Xu0Minh Duc Pham1Vincenzo Corbo2Mariano Ponz-Sarvise3Tobiloba Oni4Daniel Öhlund5Chang-Il Hwang6Department of Microbiology and Molecular Genetics, University of California, DavisDepartment of Microbiology and Molecular Genetics, University of California, DavisDepartment of Engineering for Innovation Medicine, University of VeronaDepartment of Medical Oncology and Program in Solid Tumors, Cima-Universidad de Navarra, Cancer Center Clinica Universidad de Navarra (CCUN), PamplonaWhitehead Institute for Biomedical ResearchUmeå University, Department of Diagnostics and Intervention, and Wallenberg Centre for Molecular Medicine at Umeå UniversityDepartment of Microbiology and Molecular Genetics, University of California, DavisAbstract Research on pancreatic cancer has transformed with the advent of organoid technology, providing a better platform that closely mimics cancer biology in vivo. This review highlights the critical advancements facilitated by pancreatic organoid models in understanding disease progression, evaluating therapeutic responses, and identifying biomarkers. These three-dimensional cultures enable the proper recapitulation of the cellular architecture and genetic makeup of the original tumors, providing insights into the complex molecular and cellular dynamics at various stages of pancreatic ductal adenocarcinoma (PDAC). We explore the applications of pancreatic organoids in dissecting the tumor microenvironment (TME); elucidating cancer progression, metastasis, and drug resistance mechanisms; and personalizing therapeutic strategies. By overcoming the limitations of traditional 2D cultures and animal models, the use of pancreatic organoids has significantly accelerated translational research, which is promising for improving diagnostic and therapeutic approaches in clinical settings, ultimately aiming to improve the outcomes of patients with pancreatic cancer.https://doi.org/10.1038/s12276-024-01378-w |
| spellingShingle | Jihao Xu Minh Duc Pham Vincenzo Corbo Mariano Ponz-Sarvise Tobiloba Oni Daniel Öhlund Chang-Il Hwang Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology Experimental and Molecular Medicine |
| title | Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology |
| title_full | Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology |
| title_fullStr | Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology |
| title_full_unstemmed | Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology |
| title_short | Advancing pancreatic cancer research and therapeutics: the transformative role of organoid technology |
| title_sort | advancing pancreatic cancer research and therapeutics the transformative role of organoid technology |
| url | https://doi.org/10.1038/s12276-024-01378-w |
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