Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy
Abstract Nanozymes offer diverse therapeutic potentials for cancer treatment which is dependent on the development of nanomaterials. Quasi-metal-organic framework is a class of metal-organic framework-derived nanomaterials with a transition state from metal-organic frameworks towards metal oxide fea...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57542-x |
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| author | Zihui Yan Yang Bai Songtao Zhang Lingyi Kong Yu Wang Huilin Sun Yi Li Lin Qiu Ruijie Zhang Pengju Jiang Donghui Zhao Zhongyan Chen Yafei Li Huan Pang Jianhao Wang |
| author_facet | Zihui Yan Yang Bai Songtao Zhang Lingyi Kong Yu Wang Huilin Sun Yi Li Lin Qiu Ruijie Zhang Pengju Jiang Donghui Zhao Zhongyan Chen Yafei Li Huan Pang Jianhao Wang |
| author_sort | Zihui Yan |
| collection | DOAJ |
| description | Abstract Nanozymes offer diverse therapeutic potentials for cancer treatment which is dependent on the development of nanomaterials. Quasi-metal-organic framework is a class of metal-organic framework-derived nanomaterials with a transition state from metal-organic frameworks towards metal oxide featuring porous structure and high activity. Herein an iron-based quasi-metal-organic framework nanozyme Q-MIL-53(Fe) is reported via a controlled deligandation strategy, exhibiting enhanced peroxidase-/catalase-mimic activity and glutathione depletion capacity, whose underlying mechanisms are studied via density functional theory calculations. Q-MIL-53(Fe) demonstrates biocompatibility and superior antitumor efficacy compared to pristine MIL-53(Fe). It can activate antitumor immune response by inducing ferroptosis and immunogenic cell death, promoting dendritic cell maturation and T lymphocytes infiltration. Furthermore, a combination of Q-MIL-53(Fe) and programmed cell death protein 1 antibody amplifies cancer immunotherapy. This study validates the antitumor activity of quasi-metal-organic frameworks and its immunotherapy induction potential. It would broaden the application of quasi-metal-organic frameworks and open avenues for developing antitumor nanozymes. |
| format | Article |
| id | doaj-art-1738e9ae4068447fb8acacc0fbe2e144 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-1738e9ae4068447fb8acacc0fbe2e1442025-08-20T01:57:27ZengNature PortfolioNature Communications2041-17232025-03-0116111910.1038/s41467-025-57542-xQuasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapyZihui Yan0Yang Bai1Songtao Zhang2Lingyi Kong3Yu Wang4Huilin Sun5Yi Li6Lin Qiu7Ruijie Zhang8Pengju Jiang9Donghui Zhao10Zhongyan Chen11Yafei Li12Huan Pang13Jianhao Wang14School of Pharmacy, Changzhou UniversitySchool of Pharmacy, Changzhou UniversitySchool of Chemistry and Chemical Engineering, Yangzhou UniversityJiangsu Collaborative Innovation Centre of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal UniversityJiangsu Collaborative Innovation Centre of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal UniversitySchool of Pharmacy, Changzhou UniversitySchool of Pharmacy, Changzhou UniversitySchool of Pharmacy, Changzhou UniversitySchool of Pharmacy, Changzhou UniversitySchool of Pharmacy, Changzhou UniversitySchool of Pharmacy, Changzhou UniversityCollege of Chemistry and Materials Engineering, Wenzhou UniversitySchool of Pharmacy, Changzhou UniversitySchool of Chemistry and Chemical Engineering, Yangzhou UniversitySchool of Pharmacy, Changzhou UniversityAbstract Nanozymes offer diverse therapeutic potentials for cancer treatment which is dependent on the development of nanomaterials. Quasi-metal-organic framework is a class of metal-organic framework-derived nanomaterials with a transition state from metal-organic frameworks towards metal oxide featuring porous structure and high activity. Herein an iron-based quasi-metal-organic framework nanozyme Q-MIL-53(Fe) is reported via a controlled deligandation strategy, exhibiting enhanced peroxidase-/catalase-mimic activity and glutathione depletion capacity, whose underlying mechanisms are studied via density functional theory calculations. Q-MIL-53(Fe) demonstrates biocompatibility and superior antitumor efficacy compared to pristine MIL-53(Fe). It can activate antitumor immune response by inducing ferroptosis and immunogenic cell death, promoting dendritic cell maturation and T lymphocytes infiltration. Furthermore, a combination of Q-MIL-53(Fe) and programmed cell death protein 1 antibody amplifies cancer immunotherapy. This study validates the antitumor activity of quasi-metal-organic frameworks and its immunotherapy induction potential. It would broaden the application of quasi-metal-organic frameworks and open avenues for developing antitumor nanozymes.https://doi.org/10.1038/s41467-025-57542-x |
| spellingShingle | Zihui Yan Yang Bai Songtao Zhang Lingyi Kong Yu Wang Huilin Sun Yi Li Lin Qiu Ruijie Zhang Pengju Jiang Donghui Zhao Zhongyan Chen Yafei Li Huan Pang Jianhao Wang Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy Nature Communications |
| title | Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy |
| title_full | Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy |
| title_fullStr | Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy |
| title_full_unstemmed | Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy |
| title_short | Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy |
| title_sort | quasi fe mil 53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy |
| url | https://doi.org/10.1038/s41467-025-57542-x |
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