Hongyuyin attenuates intestinal fibrosis in ulcerative colitis in mice revealed by transcriptomic and network pharmacology analyses

Hongyuyin attenuates intestinal fibrosis in ulcerative colitis in mice revealed by transcriptomic and network pharmacology analyses

Abstract Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease affecting the gastrointestinal tract. Hongyuyin (HYY), a traditional Chinese botanical formulation, has been effectively treating UC for over three decades; however, its underlying biological mechanism of action in UC-ass...

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Bibliographic Details
Main Authors: Qin Qin, Qingjun Dong, Yan Pan, Chen Wang, Jingen Lu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ulcerative colitis
Intestinal fibrosis
PI3K
AKT
Transcriptomics
Network pharmacology
Online Access:https://doi.org/10.1038/s41598-025-06021-w
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