Kynurenic Acid Synthesis from D-Kynurenine in the Cerebellum: A Distinct Role of D-Amino Acid Oxidase

Kynurenic Acid Synthesis from D-Kynurenine in the Cerebellum: A Distinct Role of D-Amino Acid Oxidase

The enzymatic formation of kynurenic acid (KYNA), a neuromodulator metabolite of the kynurenine pathway (KP) of tryptophan metabolism, in the mammalian brain is widely attributed to kynurenine aminotransferase II (KATII). However, an alternative biosynthetic route, involving the conversion of D-kynu...

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Bibliographic Details
Main Authors: Verónica Pérez de la Cruz, Korrapati V. Sathyasaikumar, Xiao-Dan Wang, Tonali Blanco Ayala, Sarah Beggiato, Dinora F. González Esquivel, Benjamin Pineda, Robert Schwarcz
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
D-amino acid oxidase
kynurenic acid
cerebellum
D-kynurenine
Online Access:https://www.mdpi.com/2073-4409/14/13/1030
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