Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection
Summary: Neural representations for visual stimuli typically emerge with a bilateral distribution across occipitotemporal cortex (OTC). Pediatric patients undergoing unilateral OTC resection offer an opportunity to evaluate whether representations for visual stimulus individuation can sufficiently d...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224026658 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850244808063320064 |
|---|---|
| author | Michael C. Granovetter Anne Margarette S. Maallo Shouyu Ling Sophia Robert Erez Freud Christina Patterson Marlene Behrmann |
| author_facet | Michael C. Granovetter Anne Margarette S. Maallo Shouyu Ling Sophia Robert Erez Freud Christina Patterson Marlene Behrmann |
| author_sort | Michael C. Granovetter |
| collection | DOAJ |
| description | Summary: Neural representations for visual stimuli typically emerge with a bilateral distribution across occipitotemporal cortex (OTC). Pediatric patients undergoing unilateral OTC resection offer an opportunity to evaluate whether representations for visual stimulus individuation can sufficiently develop in a single OTC. Here, we assessed the non-resected hemisphere of patients with pediatric resection within (n = 9) and outside (n = 12) OTC, as well as healthy controls’ two hemispheres (n = 21). Using functional magnetic resonance imaging, we mapped category selectivity (CS), and representations for visual stimulus individuation (for faces, objects, and words) with repetition suppression (RS). There were no group differences in CS or RS. However, OTC resection patients’ accuracy on face and object (but not word) recognition was lower than controls’. The neuroimaging results highlight neural resilience following damage to the contralateral homologue. Critically, however, a single OTC does not suffice for typical behavior, and, thereby, implicates the necessary contributions of bilateral OTC for visual recognition. |
| format | Article |
| id | doaj-art-172eeccd76dc4646835f12a15437b8aa |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-172eeccd76dc4646835f12a15437b8aa2025-08-20T01:59:39ZengElsevieriScience2589-00422024-12-01271211144010.1016/j.isci.2024.111440Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resectionMichael C. Granovetter0Anne Margarette S. Maallo1Shouyu Ling2Sophia Robert3Erez Freud4Christina Patterson5Marlene Behrmann6Department of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA; School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Departments of Pediatrics and Neurology, New York University, New York, NY 10016, USA; Corresponding authorDepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USADepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USADepartment of Psychology, York University, Toronto, ON M3J 1P3, CanadaDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Corresponding authorSummary: Neural representations for visual stimuli typically emerge with a bilateral distribution across occipitotemporal cortex (OTC). Pediatric patients undergoing unilateral OTC resection offer an opportunity to evaluate whether representations for visual stimulus individuation can sufficiently develop in a single OTC. Here, we assessed the non-resected hemisphere of patients with pediatric resection within (n = 9) and outside (n = 12) OTC, as well as healthy controls’ two hemispheres (n = 21). Using functional magnetic resonance imaging, we mapped category selectivity (CS), and representations for visual stimulus individuation (for faces, objects, and words) with repetition suppression (RS). There were no group differences in CS or RS. However, OTC resection patients’ accuracy on face and object (but not word) recognition was lower than controls’. The neuroimaging results highlight neural resilience following damage to the contralateral homologue. Critically, however, a single OTC does not suffice for typical behavior, and, thereby, implicates the necessary contributions of bilateral OTC for visual recognition.http://www.sciencedirect.com/science/article/pii/S2589004224026658NeuroscienceSensory neuroscience |
| spellingShingle | Michael C. Granovetter Anne Margarette S. Maallo Shouyu Ling Sophia Robert Erez Freud Christina Patterson Marlene Behrmann Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection iScience Neuroscience Sensory neuroscience |
| title | Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection |
| title_full | Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection |
| title_fullStr | Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection |
| title_full_unstemmed | Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection |
| title_short | Functional resilience of the neural visual recognition system post-pediatric occipitotemporal resection |
| title_sort | functional resilience of the neural visual recognition system post pediatric occipitotemporal resection |
| topic | Neuroscience Sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224026658 |
| work_keys_str_mv | AT michaelcgranovetter functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection AT annemargarettesmaallo functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection AT shouyuling functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection AT sophiarobert functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection AT erezfreud functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection AT christinapatterson functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection AT marlenebehrmann functionalresilienceoftheneuralvisualrecognitionsystempostpediatricoccipitotemporalresection |