Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of Echinococcus multilocularis

Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen of Echinococcus multilocularis

Alveolar echinococcosis (AE) caused by Echinococcus multilocularis, is a severe zoonotic disease in humans. One of the major metacestode antigens of E. multilocularis is the Em2 or Em2(G11) native purified antigen. The Em2 antigen is used for the serological and histopathological diagnosis of AE in...

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Bibliographic Details
Main Authors: Philipp A. Kronenberg, Teivi Laurimäe, Michael Reinehr, Ansgar Deibel, Sina Hasler, Peter Gehrig, Achim Weber, Peter Deplazes, Ramon M. Eichenberger
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Parasitology
Subjects:
Em2
mAbEm2G11
monoclonal antibody
proteomics
LC-MS
deglycosylation
Online Access:https://www.frontiersin.org/articles/10.3389/fpara.2025.1540215/full
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