Metformin-improved cognitive impairment in patients with schizophrenia is correlated with activation of tricarboxylic acid cycle and restored functional connectivity of hippocampus

Metformin-improved cognitive impairment in patients with schizophrenia is correlated with activation of tricarboxylic acid cycle and restored functional connectivity of hippocampus

Abstract Background Cognitive impairment is a prominent feature that adversely affects the long-term prognosis of schizophrenia; yet effective clinical strategies for treatment remain limited. Disruptions in the tricarboxylic acid (TCA) cycle and functional brain abnormalities in the hippocampus may...

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Main Authors: Jingda Cai, Jingmei Xiao, Yujun Long, Ting Cao, Chenquan Lin, Gangrui Hei, Weiyan Wang, Dongyu Kang, Jing Huang, Tiannan Shao, Hualin Cai, Renrong Wu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Medicine
Subjects:
Schizophrenia
Metformin
Tricarboxylic acid cycle
Functional connectivity
Hippocampus
Cognition
Online Access:https://doi.org/10.1186/s12916-025-04218-4
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