Low plasma levels of BTLA and LAG-3 before HCV therapy are associated with metabolic disorders after HCV eradication in persons with HIV/HCV coinfection: a retrospective study

Low plasma levels of BTLA and LAG-3 before HCV therapy are associated with metabolic disorders after HCV eradication in persons with HIV/HCV coinfection: a retrospective study

BackgroundUnderstanding the predictors of metabolic disorders in persons with HIV/HCV coinfection post-HCV therapy is crucial for improving patient outcomes. Since immune checkpoint proteins are usually upregulated in these persons with HIV/HCV coinfection, we aimed to evaluate the association betwe...

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Main Authors: Rubén Martín-Escolano, Ana Virseda-Berdices, Juan Berenguer, Juan González-García, Oscar Brochado-Kith, Amanda Fernández-Rodríguez, Cristina Díez, Victor Hontañon, The Marathon Study Group, Salvador Resino, María Ángeles Jiménez-Sousa, A. Arranz, F. Arnalich, J. R. Arribas, E. Aznar, T. Aldamiz-Echevarría, J. Bermejo, J. Berenguer, J. M. Bellón, I. Bernardino, M. J. Bustinduy, A. Carrero, S. Carretero, E. Casas, J. L. Casado, M. Crespo, P. Crespo, C. Díez, M. Díaz, J. de Miguel, F. Dronda, H. Esteban, C. Fanciulli, A. Ferrer, M. J. Galindo, J. González-García, I. Gutiérrez, . A. Iribarren, V. Hontañón, C. López, P. Miralles, M. L. Montes, A. Moreno, S. Moreno, L. Ortiz, E. Ortega, B Padilla, J. F. Parras, L. Pérez-Latorre, F. Pascual, M. Pérez, M. J. Pérez-Elías, J. M. Peña, C. Quereda, M. Ramírez, E. Ribera, J. F. Rodríguez-Arrondo, J. Sanz, I. Santos, M. A. Sanfrutos, S. Schroeder, F. Tejerina, M. J. Téllez, E. Van den Eynde, J. Vergas, M. A. Von-Wichmann, M. Yllescas, J. F. Zamora
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
HIV/HCV-coinfection
HCV therapy
immune checkpoint proteins
type 2 diabetes mellitus
dyslipidemia
TyG index
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1341612/full
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