The Link Between Endoplasmic Reticulum Stress and Lysosomal Dysfunction Under Oxidative Stress in Cancer Cells

The Link Between Endoplasmic Reticulum Stress and Lysosomal Dysfunction Under Oxidative Stress in Cancer Cells

Lysosomal dysfunction and endoplasmic reticulum (ER) stress play essential roles in cancer cell survival, growth, and stress adaptation. Among the various stressors in the tumor microenvironment, oxidative stress (OS) is a central driver that exacerbates both lysosomal and ER dysfunction. In healthy...

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Bibliographic Details
Main Authors: Mariapia Vietri, Maria Rosaria Miranda, Giuseppina Amodio, Tania Ciaglia, Alessia Bertamino, Pietro Campiglia, Paolo Remondelli, Vincenzo Vestuto, Ornella Moltedo
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
lysosomal dysfunction
oxidative stress
ER stress
autophagy
LMP
cancer
Online Access:https://www.mdpi.com/2218-273X/15/7/930
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