A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex
Abstract Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of computational processes. Pairwise spike-time statistical relationships, across the population, can be summarized as a functio...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54343-6 |
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| author | Dalton D. Moore Jason N. MacLean Jeffrey D. Walker Nicholas G. Hatsopoulos |
| author_facet | Dalton D. Moore Jason N. MacLean Jeffrey D. Walker Nicholas G. Hatsopoulos |
| author_sort | Dalton D. Moore |
| collection | DOAJ |
| description | Abstract Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of computational processes. Pairwise spike-time statistical relationships, across the population, can be summarized as a functional network (FN) which retains single-unit properties. We record populations of single-unit neural activity in marmoset forelimb sensorimotor cortex during prey capture and spontaneous behavior and use an encoding model incorporating kinematic trajectories and network features to predict single-unit activity during forelimb movements. The contribution of network features depends on structured connectivity within strongly connected functional groups. We identify a context-specific functional group that is highly tuned to kinematics and reorganizes its connectivity between spontaneous and prey capture movements. In the remaining context-invariant group, interactions are comparatively stable across behaviors and units are less tuned to kinematics. This suggests different roles in producing natural forelimb movements and contextualizes single-unit tuning properties within population dynamics. |
| format | Article |
| id | doaj-art-1720faade1244cdab1f98328471dcf34 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-1720faade1244cdab1f98328471dcf342024-12-08T12:36:51ZengNature PortfolioNature Communications2041-17232024-12-0115111610.1038/s41467-024-54343-6A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortexDalton D. Moore0Jason N. MacLean1Jeffrey D. Walker2Nicholas G. Hatsopoulos3Department of Organismal Biology and Anatomy, University of ChicagoCommittee on Computational Neuroscience, University of ChicagoDepartment of Organismal Biology and Anatomy, University of ChicagoDepartment of Organismal Biology and Anatomy, University of ChicagoAbstract Mechanisms of computation in sensorimotor cortex must be flexible and robust to support skilled motor behavior. Patterns of neuronal coactivity emerge as a result of computational processes. Pairwise spike-time statistical relationships, across the population, can be summarized as a functional network (FN) which retains single-unit properties. We record populations of single-unit neural activity in marmoset forelimb sensorimotor cortex during prey capture and spontaneous behavior and use an encoding model incorporating kinematic trajectories and network features to predict single-unit activity during forelimb movements. The contribution of network features depends on structured connectivity within strongly connected functional groups. We identify a context-specific functional group that is highly tuned to kinematics and reorganizes its connectivity between spontaneous and prey capture movements. In the remaining context-invariant group, interactions are comparatively stable across behaviors and units are less tuned to kinematics. This suggests different roles in producing natural forelimb movements and contextualizes single-unit tuning properties within population dynamics.https://doi.org/10.1038/s41467-024-54343-6 |
| spellingShingle | Dalton D. Moore Jason N. MacLean Jeffrey D. Walker Nicholas G. Hatsopoulos A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex Nature Communications |
| title | A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex |
| title_full | A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex |
| title_fullStr | A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex |
| title_full_unstemmed | A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex |
| title_short | A dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex |
| title_sort | dynamic subset of network interactions underlies tuning to natural movements in marmoset sensorimotor cortex |
| url | https://doi.org/10.1038/s41467-024-54343-6 |
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