Allele-specific depletion of GNAQQ209L via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQQ209L uveal melanoma cells
Approximately 80%–90% of uveal melanomas (UVM) harbor a single base pair substitution in one of two Gα protein subunits (GNAQQ209L/P/GNA11Q209L), resulting in constitutive activation and tumor initiation/progression. Herein, a small interfering RNA (siRNA) that specifically targets GNAQQ209L transcr...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Molecular Therapy: Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S295032992500089X |
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