Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease
Type 2 diabetes mellitus patients with coronary artery disease have become a major public health concern. The occurrence of insulin resistance accompanied with endothelial dysfunction worsens the state of atherosclerosis in type 2 diabetes mellitus patients. The combination of insulin resistance and...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/698567 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557148789276672 |
|---|---|
| author | Sharifah Intan Qhadijah Syed Ikmal Hasniza Zaman Huri Shireene Ratna Vethakkan Wan Azman Wan Ahmad |
| author_facet | Sharifah Intan Qhadijah Syed Ikmal Hasniza Zaman Huri Shireene Ratna Vethakkan Wan Azman Wan Ahmad |
| author_sort | Sharifah Intan Qhadijah Syed Ikmal |
| collection | DOAJ |
| description | Type 2 diabetes mellitus patients with coronary artery disease have become a major public health concern. The occurrence of insulin resistance accompanied with endothelial dysfunction worsens the state of atherosclerosis in type 2 diabetes mellitus patients. The combination of insulin resistance and endothelial dysfunction leads to coronary artery disease and ischemic heart disease complications. A recognized biological marker, high-sensitivity C-reactive protein, has been used widely to assess the progression of atherosclerosis and inflammation. Along with coronary arterial damage and inflammatory processes, high-sensitivity C-reactive protein is considered as an essential atherosclerosis marker in patients with cardiovascular disease, but not as an insulin resistance marker in type 2 diabetes mellitus patients. A new biological marker that can act as a reliable indicator of both the exact state of insulin resistance and atherosclerosis is required to facilitate optimal health management of diabetic patients. Malfunctioning of insulin mechanism and endothelial dysfunction leads to innate immune activation and released several biological markers into circulation. This review examines potential biological markers, YKL-40, alpha-hydroxybutyrate, soluble CD36, leptin, resistin, interleukin-18, retinol binding protein-4, and chemerin, as they may play significant roles in insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease. |
| format | Article |
| id | doaj-art-1711b86c3b214ab99a06695cff0bfa52 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1711b86c3b214ab99a06695cff0bfa522025-02-03T05:43:32ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/698567698567Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery DiseaseSharifah Intan Qhadijah Syed Ikmal0Hasniza Zaman Huri1Shireene Ratna Vethakkan2Wan Azman Wan Ahmad3Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaDepartment of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaEndocrinology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MalaysiaClinical Investigation Centre, 13th Floor Main Tower, University Malaya Medical Centre, 59100 Lembah Pantai, Kuala Lumpur, MalaysiaType 2 diabetes mellitus patients with coronary artery disease have become a major public health concern. The occurrence of insulin resistance accompanied with endothelial dysfunction worsens the state of atherosclerosis in type 2 diabetes mellitus patients. The combination of insulin resistance and endothelial dysfunction leads to coronary artery disease and ischemic heart disease complications. A recognized biological marker, high-sensitivity C-reactive protein, has been used widely to assess the progression of atherosclerosis and inflammation. Along with coronary arterial damage and inflammatory processes, high-sensitivity C-reactive protein is considered as an essential atherosclerosis marker in patients with cardiovascular disease, but not as an insulin resistance marker in type 2 diabetes mellitus patients. A new biological marker that can act as a reliable indicator of both the exact state of insulin resistance and atherosclerosis is required to facilitate optimal health management of diabetic patients. Malfunctioning of insulin mechanism and endothelial dysfunction leads to innate immune activation and released several biological markers into circulation. This review examines potential biological markers, YKL-40, alpha-hydroxybutyrate, soluble CD36, leptin, resistin, interleukin-18, retinol binding protein-4, and chemerin, as they may play significant roles in insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease.http://dx.doi.org/10.1155/2013/698567 |
| spellingShingle | Sharifah Intan Qhadijah Syed Ikmal Hasniza Zaman Huri Shireene Ratna Vethakkan Wan Azman Wan Ahmad Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease International Journal of Endocrinology |
| title | Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease |
| title_full | Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease |
| title_fullStr | Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease |
| title_full_unstemmed | Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease |
| title_short | Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease |
| title_sort | potential biomarkers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease |
| url | http://dx.doi.org/10.1155/2013/698567 |
| work_keys_str_mv | AT sharifahintanqhadijahsyedikmal potentialbiomarkersofinsulinresistanceandatherosclerosisintype2diabetesmellituspatientswithcoronaryarterydisease AT hasnizazamanhuri potentialbiomarkersofinsulinresistanceandatherosclerosisintype2diabetesmellituspatientswithcoronaryarterydisease AT shireeneratnavethakkan potentialbiomarkersofinsulinresistanceandatherosclerosisintype2diabetesmellituspatientswithcoronaryarterydisease AT wanazmanwanahmad potentialbiomarkersofinsulinresistanceandatherosclerosisintype2diabetesmellituspatientswithcoronaryarterydisease |