Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients
Objective. To examine the relationship of handgrip strength with forearm blood flow (BF) and vascular resistance (VR) in rheumatoid arthritis (RA) patients. Methods. Forearm BF at rest (RBF) and after upper arm occlusion (RHBF), and handgrip strength were examined in 78 individuals (RA=42 and contro...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/580863 |
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| author | Mahmoud A. Alomari Esraa F. Keewan Rania A. Shammaa Khaldoon Alawneh Said Y. Khatib Michael A. Welsch |
| author_facet | Mahmoud A. Alomari Esraa F. Keewan Rania A. Shammaa Khaldoon Alawneh Said Y. Khatib Michael A. Welsch |
| author_sort | Mahmoud A. Alomari |
| collection | DOAJ |
| description | Objective. To examine the relationship of handgrip strength with forearm blood flow (BF) and vascular resistance (VR) in rheumatoid arthritis (RA) patients. Methods. Forearm BF at rest (RBF) and after upper arm occlusion (RHBF), and handgrip strength were examined in 78 individuals (RA=42 and controls (CT)=36). Subsequently, VR at rest (RVR) and after occlusion (RHVR) were calculated. Results. The patients’ RBF (P=0.02) and RHBF (P=0.0001) were less, whereas RVR (P=0.002) and RHVR (P=0.0001) were greater as compared to the CTs. Similarly, handgrip strength was lower in the RAs (P=0.0001). Finally, handgrip strength was directly associated with RBF (r=0.43; P=0.0001), and RHBF (r=0.5; P=0.0001), and inversely related to RVR (r=-0.3; P=0.009) and RHVR (r=-0.3; P=0.007). Conclusion. The present study uniquely identifies an association between regional measures of forearm blood flow and handgrip strength in patients and healthy control. In addition, this study confirms the presence of vascular and muscle dysfunction in patients with rheumatoid arthritis, as evidenced by lower forearm blood flow indices, at rest and following occlusion, and lower handgrip strength as compared to healthy individuals. |
| format | Article |
| id | doaj-art-1705c75f509a4c778cf36bedf92cface |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1705c75f509a4c778cf36bedf92cface2025-02-03T01:26:15ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/580863580863Vascular Function and Handgrip Strength in Rheumatoid Arthritis PatientsMahmoud A. Alomari0Esraa F. Keewan1Rania A. Shammaa2Khaldoon Alawneh3Said Y. Khatib4Michael A. Welsch5Division of Physical Therapy, Department of Allied Medical Sciences, Jordan University of Science and Technology, Irbid 22110, JordanDivision of Physical Therapy, Department of Allied Medical Sciences, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Physiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Kinesiology, Louisiana State University, Baton Rouge, LA 70803, USAObjective. To examine the relationship of handgrip strength with forearm blood flow (BF) and vascular resistance (VR) in rheumatoid arthritis (RA) patients. Methods. Forearm BF at rest (RBF) and after upper arm occlusion (RHBF), and handgrip strength were examined in 78 individuals (RA=42 and controls (CT)=36). Subsequently, VR at rest (RVR) and after occlusion (RHVR) were calculated. Results. The patients’ RBF (P=0.02) and RHBF (P=0.0001) were less, whereas RVR (P=0.002) and RHVR (P=0.0001) were greater as compared to the CTs. Similarly, handgrip strength was lower in the RAs (P=0.0001). Finally, handgrip strength was directly associated with RBF (r=0.43; P=0.0001), and RHBF (r=0.5; P=0.0001), and inversely related to RVR (r=-0.3; P=0.009) and RHVR (r=-0.3; P=0.007). Conclusion. The present study uniquely identifies an association between regional measures of forearm blood flow and handgrip strength in patients and healthy control. In addition, this study confirms the presence of vascular and muscle dysfunction in patients with rheumatoid arthritis, as evidenced by lower forearm blood flow indices, at rest and following occlusion, and lower handgrip strength as compared to healthy individuals.http://dx.doi.org/10.1100/2012/580863 |
| spellingShingle | Mahmoud A. Alomari Esraa F. Keewan Rania A. Shammaa Khaldoon Alawneh Said Y. Khatib Michael A. Welsch Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients The Scientific World Journal |
| title | Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients |
| title_full | Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients |
| title_fullStr | Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients |
| title_full_unstemmed | Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients |
| title_short | Vascular Function and Handgrip Strength in Rheumatoid Arthritis Patients |
| title_sort | vascular function and handgrip strength in rheumatoid arthritis patients |
| url | http://dx.doi.org/10.1100/2012/580863 |
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