Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis
To date, there is no report on safety of Artemisia Kopetdaghensis. This study aimed to determine the possible undesirable effects of A. Kopetdaghensis on reproduction of female rats. The pregnant rats were treated (i.p.) with vehicle or 200 and 400 mg/kg of A. Kopetdaghensis hydroalcoholic extract f...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2014/745760 |
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| author | Davood Oliaee Mohammad Taher Boroushaki Naiime Oliaee Ahmad Ghorbani |
| author_facet | Davood Oliaee Mohammad Taher Boroushaki Naiime Oliaee Ahmad Ghorbani |
| author_sort | Davood Oliaee |
| collection | DOAJ |
| description | To date, there is no report on safety of Artemisia Kopetdaghensis. This study aimed to determine the possible undesirable effects of A. Kopetdaghensis on reproduction of female rats. The pregnant rats were treated (i.p.) with vehicle or 200 and 400 mg/kg of A. Kopetdaghensis hydroalcoholic extract from the 2nd to 8th day of pregnancy. Then, number and weight of neonates, duration of pregnancy, and percent of dead fetuses were determined. Also, cytotoxicity of this plant was tested using fibroblast (L929) and ovary (Cho) cell lines. The A. Kopetdaghensis had no significant effect on duration of pregnancy, average number of neonates, and weight of neonates. However, administration of 200 and 400 mg/kg of the extract led to 30 and 44% abortion in animals, respectively. The extract at concentrations ≥200 μg/mL significantly (P<0.001) inhibited the proliferation of L929 fibroblast cells. Regarding the Cho cells, the extract induced toxicity only at concentration of 800 μg/mL (P<0.01). Our results showed that continuous consumption of A. Kopetdaghensis in pregnancy may increase the risk of abortion and also may have toxic effect on some cells. |
| format | Article |
| id | doaj-art-1701b5b9d75141a78674368200a97279 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-1701b5b9d75141a78674368200a972792025-02-03T07:25:27ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422014-01-01201410.1155/2014/745760745760Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensisDavood Oliaee0Mohammad Taher Boroushaki1Naiime Oliaee2Ahmad Ghorbani3Student Research Committee, Mashhad University of Medical Sciences, Mashhad 913750345, IranPharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranPharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranPharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, IranTo date, there is no report on safety of Artemisia Kopetdaghensis. This study aimed to determine the possible undesirable effects of A. Kopetdaghensis on reproduction of female rats. The pregnant rats were treated (i.p.) with vehicle or 200 and 400 mg/kg of A. Kopetdaghensis hydroalcoholic extract from the 2nd to 8th day of pregnancy. Then, number and weight of neonates, duration of pregnancy, and percent of dead fetuses were determined. Also, cytotoxicity of this plant was tested using fibroblast (L929) and ovary (Cho) cell lines. The A. Kopetdaghensis had no significant effect on duration of pregnancy, average number of neonates, and weight of neonates. However, administration of 200 and 400 mg/kg of the extract led to 30 and 44% abortion in animals, respectively. The extract at concentrations ≥200 μg/mL significantly (P<0.001) inhibited the proliferation of L929 fibroblast cells. Regarding the Cho cells, the extract induced toxicity only at concentration of 800 μg/mL (P<0.01). Our results showed that continuous consumption of A. Kopetdaghensis in pregnancy may increase the risk of abortion and also may have toxic effect on some cells.http://dx.doi.org/10.1155/2014/745760 |
| spellingShingle | Davood Oliaee Mohammad Taher Boroushaki Naiime Oliaee Ahmad Ghorbani Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis Advances in Pharmacological Sciences |
| title | Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis |
| title_full | Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis |
| title_fullStr | Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis |
| title_full_unstemmed | Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis |
| title_short | Evaluation of Cytotoxicity and Antifertility Effect of Artemisia kopetdaghensis |
| title_sort | evaluation of cytotoxicity and antifertility effect of artemisia kopetdaghensis |
| url | http://dx.doi.org/10.1155/2014/745760 |
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