SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells

SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells

Abstract Brucella is a successful pathogen that employs a plethora of immune evasion mechanisms. This contributes to pathogenesis and persistence and limits the efficacy of available treatments. An increasing understanding of host‒pathogen interactions suggests that integrating host-directed strateg...

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Main Authors: Mengyu Zhang, Lin Qi, Junmei Li, NingQiu Yuan, Yunyi Zhai, Mingyue Hao, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Veterinary Research
Subjects:
Brucella
bovine placental trophoblast cells
SIRT2
mitochondrial apoptosis
Online Access:https://doi.org/10.1186/s13567-025-01518-8
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