Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans
RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/627150 |
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| author | Engin Baturcam Jehad Abubaker Ali Tiss Mohamed Abu-Farha Abdelkrim Khadir Fahad Al-Ghimlas Irina Al-Khairi Preethi Cherian Naser Elkum Maha Hammad Jeena John Sina Kavalakatt Cynthia Lehe Samia Warsame Kazem Behbehani Said Dermime Mohammed Dehbi |
| author_facet | Engin Baturcam Jehad Abubaker Ali Tiss Mohamed Abu-Farha Abdelkrim Khadir Fahad Al-Ghimlas Irina Al-Khairi Preethi Cherian Naser Elkum Maha Hammad Jeena John Sina Kavalakatt Cynthia Lehe Samia Warsame Kazem Behbehani Said Dermime Mohammed Dehbi |
| author_sort | Engin Baturcam |
| collection | DOAJ |
| description | RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-α, IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue. |
| format | Article |
| id | doaj-art-16f6576399ab47c9833eddc4c4dfadaf |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-16f6576399ab47c9833eddc4c4dfadaf2025-08-20T02:04:52ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/627150627150Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese HumansEngin Baturcam0Jehad Abubaker1Ali Tiss2Mohamed Abu-Farha3Abdelkrim Khadir4Fahad Al-Ghimlas5Irina Al-Khairi6Preethi Cherian7Naser Elkum8Maha Hammad9Jeena John10Sina Kavalakatt11Cynthia Lehe12Samia Warsame13Kazem Behbehani14Said Dermime15Mohammed Dehbi16Department of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitFitness and Rehabilitation Centre, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biostatistics and Epidemiology, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitKing Fahad Specialist Hospital, Dammam 15215, Saudi ArabiaDepartment of Biomedical Research, Dasman Diabetes Institute, 1180 Dasman, KuwaitRANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in the subcutaneous adipose tissue of obese compared to lean. In PBMCs, however, while the levels of RANTES mRNA and protein were comparable between both groups, CCR5 mRNA was downregulated in obese subjects (P<0.05). Physical exercise significantly reduced the expression of both RANTES and CCR5 (P<0.05) in the adipose tissue of obese individuals with a concomitant decrease in the levels of the inflammatory markers TNF-α, IL-6, and P-JNK. Circulating RANTES correlated negatively with anti-inflammatory IL-1ra (P=0.001) and positively with proinflammatory IP-10 and TBARS levels (P<0.05). Therefore, physical exercise may provide an effective approach for combating the deleterious effects associated with obesity through RANTES signaling in the adipose tissue.http://dx.doi.org/10.1155/2014/627150 |
| spellingShingle | Engin Baturcam Jehad Abubaker Ali Tiss Mohamed Abu-Farha Abdelkrim Khadir Fahad Al-Ghimlas Irina Al-Khairi Preethi Cherian Naser Elkum Maha Hammad Jeena John Sina Kavalakatt Cynthia Lehe Samia Warsame Kazem Behbehani Said Dermime Mohammed Dehbi Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans Mediators of Inflammation |
| title | Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans |
| title_full | Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans |
| title_fullStr | Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans |
| title_full_unstemmed | Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans |
| title_short | Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans |
| title_sort | physical exercise reduces the expression of rantes and its ccr5 receptor in the adipose tissue of obese humans |
| url | http://dx.doi.org/10.1155/2014/627150 |
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