Effective Gene Expression Prediction and Optimization from Protein Sequences

Effective Gene Expression Prediction and Optimization from Protein Sequences

Abstract High soluble protein expression in heterologous hosts is crucial for various research and applications. Despite considerable research on the impact of codon usage on expression levels, the relationship between protein sequence and expression is often overlooked. In this study, a novel conne...

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Bibliographic Details
Main Authors: Tuoyu Liu, Yiyang Zhang, Yanjun Li, Guoshun Xu, Han Gao, Pengtao Wang, Tao Tu, Huiying Luo, Ningfeng Wu, Bin Yao, Bo Liu, Feifei Guan, Huoqing Huang, Jian Tian
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Advanced Science
Subjects:
amino acid expression index
mutant generation
predicting protein expression
soluble expression
transfer learning
Online Access:https://doi.org/10.1002/advs.202407664
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