Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry
This review is aimed at providing an overview of the application of liquid chromatography-high resolution mass spectrometry (LC-HRMS) in the metabolomic study of cereal grains, with special emphasis on wheat, maize, barley, and rice. The significant role of untargeted metabolomics in identifying and...
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| Language: | English |
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Elsevier
2024-11-01
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| Series: | Journal of Chromatography Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391724000550 |
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| author | Desiree Bozza Davide Barboni Natasha Damiana Spadafora Simona Felletti Chiara De Luca Chiara Nosengo Greta Compagnin Alberto Cavazzini Martina Catani |
| author_facet | Desiree Bozza Davide Barboni Natasha Damiana Spadafora Simona Felletti Chiara De Luca Chiara Nosengo Greta Compagnin Alberto Cavazzini Martina Catani |
| author_sort | Desiree Bozza |
| collection | DOAJ |
| description | This review is aimed at providing an overview of the application of liquid chromatography-high resolution mass spectrometry (LC-HRMS) in the metabolomic study of cereal grains, with special emphasis on wheat, maize, barley, and rice. The significant role of untargeted metabolomics in identifying and quantifying metabolites is highlighted, thereby elucidating biochemical pathways involved in flavour, disease detection, and the development of disease-resistant varieties. The use of stable isotope labelling for enhanced compound annotation and the exploration of metabolic pathways involved in plant defence mechanisms and stress resilience are also discussed. The integration of cutting-edge analytical techniques is becoming of fundamental importance to enhance the understanding of metabolic reconfigurations in response to various conditions, thereby contributing to the improvement of cereal quality and ensuring food safety. The potential health benefits of phytochemicals in human nutrition and the role of specific metabolites as biomarkers for crop resistance and susceptibility to diseases, pests, and abiotic stresses are discussed. Overall, valuable insights into the advancement of analytical chemistry and its applications in agricultural science are provided by this review. |
| format | Article |
| id | doaj-art-16eb76a123a54fa1aa28c5c1b239f9d3 |
| institution | Kabale University |
| issn | 2772-3917 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Chromatography Open |
| spelling | doaj-art-16eb76a123a54fa1aa28c5c1b239f9d32024-12-14T06:34:09ZengElsevierJournal of Chromatography Open2772-39172024-11-016100168Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometryDesiree Bozza0Davide Barboni1Natasha Damiana Spadafora2Simona Felletti3Chiara De Luca4Chiara Nosengo5Greta Compagnin6Alberto Cavazzini7Martina Catani8Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, via L. Borsari 46, Ferrara 44121 , ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , Italy; Council for Agricultural Research and Economics, via della Navicella 2/4, Rome 00184, ItalyDepartment of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, via L. Borsari 46, 44121, Ferrara , Italy; Corresponding author.This review is aimed at providing an overview of the application of liquid chromatography-high resolution mass spectrometry (LC-HRMS) in the metabolomic study of cereal grains, with special emphasis on wheat, maize, barley, and rice. The significant role of untargeted metabolomics in identifying and quantifying metabolites is highlighted, thereby elucidating biochemical pathways involved in flavour, disease detection, and the development of disease-resistant varieties. The use of stable isotope labelling for enhanced compound annotation and the exploration of metabolic pathways involved in plant defence mechanisms and stress resilience are also discussed. The integration of cutting-edge analytical techniques is becoming of fundamental importance to enhance the understanding of metabolic reconfigurations in response to various conditions, thereby contributing to the improvement of cereal quality and ensuring food safety. The potential health benefits of phytochemicals in human nutrition and the role of specific metabolites as biomarkers for crop resistance and susceptibility to diseases, pests, and abiotic stresses are discussed. Overall, valuable insights into the advancement of analytical chemistry and its applications in agricultural science are provided by this review.http://www.sciencedirect.com/science/article/pii/S2772391724000550Liquid chromatographyHigh-resolution mass spectrometryMetabolomicsAgricultureCereals |
| spellingShingle | Desiree Bozza Davide Barboni Natasha Damiana Spadafora Simona Felletti Chiara De Luca Chiara Nosengo Greta Compagnin Alberto Cavazzini Martina Catani Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry Journal of Chromatography Open Liquid chromatography High-resolution mass spectrometry Metabolomics Agriculture Cereals |
| title | Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry |
| title_full | Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry |
| title_fullStr | Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry |
| title_full_unstemmed | Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry |
| title_short | Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry |
| title_sort | untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry |
| topic | Liquid chromatography High-resolution mass spectrometry Metabolomics Agriculture Cereals |
| url | http://www.sciencedirect.com/science/article/pii/S2772391724000550 |
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