The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair
Abstract:: Intervertebral disc degeneration (IVDD) is a prevalent chronic spinal condition characterized by the deterioration of the intervertebral discs (IVD), leading to structural damage and associated pain. This degenerative process is closely linked to oxidative stress injury, which plays a piv...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X24004560 |
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| author | Yingjie Mai Siying Wu Penghui Zhang Ningning Chen Jun Wu Fuxin Wei |
| author_facet | Yingjie Mai Siying Wu Penghui Zhang Ningning Chen Jun Wu Fuxin Wei |
| author_sort | Yingjie Mai |
| collection | DOAJ |
| description | Abstract:: Intervertebral disc degeneration (IVDD) is a prevalent chronic spinal condition characterized by the deterioration of the intervertebral discs (IVD), leading to structural damage and associated pain. This degenerative process is closely linked to oxidative stress injury, which plays a pivotal role in its onset and progression. Oxidative stress in IVDD results from the excessive production of reactive oxygen species (ROS) and impaired ROS clearance mechanisms, disrupting the redox balance within the intervertebral disc. Consequently, oxidative stress contributes to the degradation of the extracellular matrix (ECM), promotes cell apoptosis, and exacerbates disc tissue damage. Current treatment options for IVDD face significant challenges in effectively alleviating the oxidative stress-induced damage and facilitating disc tissue repair. However, recent advancements in biomaterials have opened new avenues of hope for IVDD treatment by addressing oxidative stress. In this review, we first provide an overview of the pathophysiological process of IVDD and explore the mechanisms and pathways associated with oxidative stress injury. Then, we delve into the current research on antioxidant biomaterials employed in the treatment of IVDD, and outline the advantages and limitations of hydrogel, nanomaterials, polyphenol and inorganic materials. Finally, we propose the future research direction of antioxidant biomaterials in IVDD treatment. The main idea of this review is shown in Scheme 1. |
| format | Article |
| id | doaj-art-16e84a0dba904d2ab584598fcadff1b9 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-16e84a0dba904d2ab584598fcadff1b92025-01-26T05:04:19ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-03-01451940The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repairYingjie Mai0Siying Wu1Penghui Zhang2Ningning Chen3Jun Wu4Fuxin Wei5Department of Orthopaedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, 518107, ChinaBioscience and Biomedical Engineering Thrust, The Hong Kong University of Science & Technology (Guangzhou), Nansha, Guangzhou, Guangdong Province, 511400, ChinaDepartment of Orthopaedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, 518107, ChinaDepartment of Orthopaedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, 518107, ChinaBioscience and Biomedical Engineering Thrust, The Hong Kong University of Science & Technology (Guangzhou), Nansha, Guangzhou, Guangdong Province, 511400, China; Division of Life Science, The Hong Kong University of Science & Technology, Hong Kong SAR, 999077, China; Corresponding author. Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science & Technology (Guangzhou), Nansha, Guangzhou, Guangdong Province, 511400, China.Department of Orthopaedics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, 518107, China; Corresponding author.Abstract:: Intervertebral disc degeneration (IVDD) is a prevalent chronic spinal condition characterized by the deterioration of the intervertebral discs (IVD), leading to structural damage and associated pain. This degenerative process is closely linked to oxidative stress injury, which plays a pivotal role in its onset and progression. Oxidative stress in IVDD results from the excessive production of reactive oxygen species (ROS) and impaired ROS clearance mechanisms, disrupting the redox balance within the intervertebral disc. Consequently, oxidative stress contributes to the degradation of the extracellular matrix (ECM), promotes cell apoptosis, and exacerbates disc tissue damage. Current treatment options for IVDD face significant challenges in effectively alleviating the oxidative stress-induced damage and facilitating disc tissue repair. However, recent advancements in biomaterials have opened new avenues of hope for IVDD treatment by addressing oxidative stress. In this review, we first provide an overview of the pathophysiological process of IVDD and explore the mechanisms and pathways associated with oxidative stress injury. Then, we delve into the current research on antioxidant biomaterials employed in the treatment of IVDD, and outline the advantages and limitations of hydrogel, nanomaterials, polyphenol and inorganic materials. Finally, we propose the future research direction of antioxidant biomaterials in IVDD treatment. The main idea of this review is shown in Scheme 1.http://www.sciencedirect.com/science/article/pii/S2452199X24004560Intervertebral disc degenerationBiomaterialsOxidative stressAntioxidant |
| spellingShingle | Yingjie Mai Siying Wu Penghui Zhang Ningning Chen Jun Wu Fuxin Wei The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair Bioactive Materials Intervertebral disc degeneration Biomaterials Oxidative stress Antioxidant |
| title | The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair |
| title_full | The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair |
| title_fullStr | The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair |
| title_full_unstemmed | The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair |
| title_short | The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair |
| title_sort | anti oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair |
| topic | Intervertebral disc degeneration Biomaterials Oxidative stress Antioxidant |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X24004560 |
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