Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study
Purpose This study assessed the performance of the ultrasound-guided attenuation parameter (UGAP) in diagnosing and grading hepatic steatosis in patients with metabolic dysfunctionassociated steatotic liver disease (MASLD). Magnetic resonance imaging proton density fat fraction (MRI-PDFF) served as...
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Korean Society of Ultrasound in Medicine
2025-03-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-24204.pdf |
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| author | Yun-Lin Huang Chao Sun Ying Wang Juan Cheng Shi-Wen Wang Li Wei Xiu-Yun Lu Rui Cheng Ming Wang Jian-Gao Fan Yi Dong |
| author_facet | Yun-Lin Huang Chao Sun Ying Wang Juan Cheng Shi-Wen Wang Li Wei Xiu-Yun Lu Rui Cheng Ming Wang Jian-Gao Fan Yi Dong |
| author_sort | Yun-Lin Huang |
| collection | DOAJ |
| description | Purpose This study assessed the performance of the ultrasound-guided attenuation parameter (UGAP) in diagnosing and grading hepatic steatosis in patients with metabolic dysfunctionassociated steatotic liver disease (MASLD). Magnetic resonance imaging proton density fat fraction (MRI-PDFF) served as the reference standard. Methods Patients with hepatic steatosis were enrolled in this prospective study and underwent UGAP measurements. MRI-PDFF values of ≥5%, ≥15%, and ≥25% were used as references for the diagnosis of steatosis grades ≥S1, ≥S2, and S3, respectively. Spearman correlation coefficients and area under the receiver operating characteristic curves (AUCs) were calculated. Results Between July 2023 and June 2024, the study included 88 patients (median age, 40 years; interquartile range [IQR], 36 to 46 years), of whom 54.5% (48/88) were men and 45.5% (40/88) were women. Steatosis grades exhibited the following distribution: 22.7% (20/88) had S0, 50.0% (44/88) had S1, 21.6% (19/88) had S2, and 5.7% (5/88) had S3. The success rate for UGAP measurements was 100%. The median UGAP value was 0.74 dB/cm/MHz (IQR, 0.65 to 0.82 dB/ cm/MHz), and UGAP values were positively correlated with MRI-PDFF (r=0.77, P<0.001). The AUCs of UGAP for the diagnoses of ≥S1, ≥S2, and S3 steatosis were 0.91, 0.90, and 0.88, respectively. In the subgroup analysis, 98.4% (60/61) of patients had valid controlled attenuation parameter (CAP) values. UGAP measurements were positively correlated with CAP values (r=0.65, P<0.001). Conclusion Using MRI-PDFF as the reference standard, UGAP demonstrates good diagnostic performance in the detection and grading of hepatic steatosis in patients with MASLD. |
| format | Article |
| id | doaj-art-16e48bd3d389488faaac2f44186d361d |
| institution | OA Journals |
| issn | 2288-5943 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Korean Society of Ultrasound in Medicine |
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| series | Ultrasonography |
| spelling | doaj-art-16e48bd3d389488faaac2f44186d361d2025-08-20T01:55:03ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59432025-03-0144213414410.14366/usg.242041749Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective studyYun-Lin Huang0Chao Sun1Ying Wang2Juan Cheng3Shi-Wen Wang4Li Wei5Xiu-Yun Lu6Rui Cheng7Ming Wang8Jian-Gao Fan9Yi Dong10 Department of Ultrasound, Zhongshan Hospital Fudan University, Shanghai, China Center for Fatty Liver Disease, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Center for Fatty Liver Disease, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai, China Department of Ultrasound, Zhongshan Hospital Fudan University, Shanghai, ChinaPurpose This study assessed the performance of the ultrasound-guided attenuation parameter (UGAP) in diagnosing and grading hepatic steatosis in patients with metabolic dysfunctionassociated steatotic liver disease (MASLD). Magnetic resonance imaging proton density fat fraction (MRI-PDFF) served as the reference standard. Methods Patients with hepatic steatosis were enrolled in this prospective study and underwent UGAP measurements. MRI-PDFF values of ≥5%, ≥15%, and ≥25% were used as references for the diagnosis of steatosis grades ≥S1, ≥S2, and S3, respectively. Spearman correlation coefficients and area under the receiver operating characteristic curves (AUCs) were calculated. Results Between July 2023 and June 2024, the study included 88 patients (median age, 40 years; interquartile range [IQR], 36 to 46 years), of whom 54.5% (48/88) were men and 45.5% (40/88) were women. Steatosis grades exhibited the following distribution: 22.7% (20/88) had S0, 50.0% (44/88) had S1, 21.6% (19/88) had S2, and 5.7% (5/88) had S3. The success rate for UGAP measurements was 100%. The median UGAP value was 0.74 dB/cm/MHz (IQR, 0.65 to 0.82 dB/ cm/MHz), and UGAP values were positively correlated with MRI-PDFF (r=0.77, P<0.001). The AUCs of UGAP for the diagnoses of ≥S1, ≥S2, and S3 steatosis were 0.91, 0.90, and 0.88, respectively. In the subgroup analysis, 98.4% (60/61) of patients had valid controlled attenuation parameter (CAP) values. UGAP measurements were positively correlated with CAP values (r=0.65, P<0.001). Conclusion Using MRI-PDFF as the reference standard, UGAP demonstrates good diagnostic performance in the detection and grading of hepatic steatosis in patients with MASLD.http://www.e-ultrasonography.org/upload/usg-24204.pdfultrasound-guided attenuation parametermagnetic resonance imaging proton density fat fractioncontrolled attenuation parametermetabolic dysfunction-associated steatotic liver diseasequantificationnoninvasive |
| spellingShingle | Yun-Lin Huang Chao Sun Ying Wang Juan Cheng Shi-Wen Wang Li Wei Xiu-Yun Lu Rui Cheng Ming Wang Jian-Gao Fan Yi Dong Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study Ultrasonography ultrasound-guided attenuation parameter magnetic resonance imaging proton density fat fraction controlled attenuation parameter metabolic dysfunction-associated steatotic liver disease quantification noninvasive |
| title | Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study |
| title_full | Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study |
| title_fullStr | Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study |
| title_full_unstemmed | Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study |
| title_short | Ultrasound-guided attenuation parameter for identifying metabolic dysfunction-associated steatotic liver disease: a prospective study |
| title_sort | ultrasound guided attenuation parameter for identifying metabolic dysfunction associated steatotic liver disease a prospective study |
| topic | ultrasound-guided attenuation parameter magnetic resonance imaging proton density fat fraction controlled attenuation parameter metabolic dysfunction-associated steatotic liver disease quantification noninvasive |
| url | http://www.e-ultrasonography.org/upload/usg-24204.pdf |
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