Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics
Over the past decades, oncolytic viruses have emerged as prominent therapeutic agents with significant potential for anticancer treatment. Enteroviruses (EVs) have garnered particular attention due to their specific tropism for various types of tumor cells. The rapid advancement of reverse genetics...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Biosafety and Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590053625000047 |
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| author | Shijin Wang Qing Yu Junfeng Zhou Wanshan Yang Yonggang Wang Haoran Guo Wei Wei |
| author_facet | Shijin Wang Qing Yu Junfeng Zhou Wanshan Yang Yonggang Wang Haoran Guo Wei Wei |
| author_sort | Shijin Wang |
| collection | DOAJ |
| description | Over the past decades, oncolytic viruses have emerged as prominent therapeutic agents with significant potential for anticancer treatment. Enteroviruses (EVs) have garnered particular attention due to their specific tropism for various types of tumor cells. The rapid advancement of reverse genetics has enabled its application in the genetic modification of enteroviruses and the investigation of viral infection mechanisms. The utilization of reverse genetics has significantly enhanced our understanding of the infection mechanisms and pathogenesis of enteroviruses, while concurrently facilitating the development of translational therapies related to these viruses. In this review, we summarize the progress in the application of reverse genetics to oncolytic enteroviruses and their potential clinical applications. Specifically, we discuss the characteristics of EVs and the applications of reverse genetics in EV research. We review the utilization of reverse genetics in mechanistic investigations of EVs and in exploring the oncolytic potential of EVs. Further, we discuss the oncolytic roles of specific EVs including EV-A71, coxsackievirus B3 (CV-B3), echovirus 7 (Echo-7), CV-A21, and poliovirus. Our review highlights the advances in oncolytic therapy utilizing EVs with specific tumor tropism, which holds significant potential for immunotherapy. |
| format | Article |
| id | doaj-art-16e297d016104f1b9cdb279a01a015d5 |
| institution | OA Journals |
| issn | 2590-0536 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biosafety and Health |
| spelling | doaj-art-16e297d016104f1b9cdb279a01a015d52025-08-20T02:11:11ZengElsevierBiosafety and Health2590-05362025-02-0171748210.1016/j.bsheal.2025.01.004Exploring enterovirus pathogenesis and cancer therapy potential through reverse geneticsShijin Wang0Qing Yu1Junfeng Zhou2Wanshan Yang3Yonggang Wang4Haoran Guo5Wei Wei6Cancer Center, The First Hospital of Jilin University, Changchun 130021 China; Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun 130021 ChinaInstitute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun 130021 China; Department of Pathology, Medical College, Yanbian University, Yanji 136200 ChinaDepartment of Dermatology, The First Hospital of Jilin University, Changchun 130021 ChinaDepartment of Pathology, Medical College, Yanbian University, Yanji 136200 ChinaDepartment of Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021 ChinaCancer Center, The First Hospital of Jilin University, Changchun 130021 China; Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun 130021 ChinaCancer Center, The First Hospital of Jilin University, Changchun 130021 China; Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun 130021 China; Institute of Translational Medicine, Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, The First Hospital of Jilin University, Changchun 130021 China; Corresponding author: Cancer Center, The First Hospital of Jilin University, Changchun 130021, China.Over the past decades, oncolytic viruses have emerged as prominent therapeutic agents with significant potential for anticancer treatment. Enteroviruses (EVs) have garnered particular attention due to their specific tropism for various types of tumor cells. The rapid advancement of reverse genetics has enabled its application in the genetic modification of enteroviruses and the investigation of viral infection mechanisms. The utilization of reverse genetics has significantly enhanced our understanding of the infection mechanisms and pathogenesis of enteroviruses, while concurrently facilitating the development of translational therapies related to these viruses. In this review, we summarize the progress in the application of reverse genetics to oncolytic enteroviruses and their potential clinical applications. Specifically, we discuss the characteristics of EVs and the applications of reverse genetics in EV research. We review the utilization of reverse genetics in mechanistic investigations of EVs and in exploring the oncolytic potential of EVs. Further, we discuss the oncolytic roles of specific EVs including EV-A71, coxsackievirus B3 (CV-B3), echovirus 7 (Echo-7), CV-A21, and poliovirus. Our review highlights the advances in oncolytic therapy utilizing EVs with specific tumor tropism, which holds significant potential for immunotherapy.http://www.sciencedirect.com/science/article/pii/S2590053625000047Reverse geneticsEnterovirus (EV)Oncolytic virus (OV)PathogenesisTumor immunity |
| spellingShingle | Shijin Wang Qing Yu Junfeng Zhou Wanshan Yang Yonggang Wang Haoran Guo Wei Wei Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics Biosafety and Health Reverse genetics Enterovirus (EV) Oncolytic virus (OV) Pathogenesis Tumor immunity |
| title | Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics |
| title_full | Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics |
| title_fullStr | Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics |
| title_full_unstemmed | Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics |
| title_short | Exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics |
| title_sort | exploring enterovirus pathogenesis and cancer therapy potential through reverse genetics |
| topic | Reverse genetics Enterovirus (EV) Oncolytic virus (OV) Pathogenesis Tumor immunity |
| url | http://www.sciencedirect.com/science/article/pii/S2590053625000047 |
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