Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access
Background. Angiogenic factors following oncological surgery is important in tumor recurrence. Vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), Ang-2, soluble VEGF-receptor 1 (sVEGFR1) and sVEGFR2 may influence angiogenesis. This prospective study examined the influence of open and...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/636754 |
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| author | Calvin S. H. Ng Song Wan Randolph H. L. Wong Anthony M. H. Ho Anthony P. C. Yim |
| author_facet | Calvin S. H. Ng Song Wan Randolph H. L. Wong Anthony M. H. Ho Anthony P. C. Yim |
| author_sort | Calvin S. H. Ng |
| collection | DOAJ |
| description | Background. Angiogenic factors following oncological surgery is important in tumor recurrence. Vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), Ang-2, soluble VEGF-receptor 1 (sVEGFR1) and sVEGFR2 may influence angiogenesis. This prospective study examined the influence of open and video-assisted thoracic surgery (VATS) lung resections for early stage non-small cell lung cancer (NSCLC) on postoperative circulating angiogenic factors. Methods. Forty-three consecutive patients underwent major lung resection through either VATS (𝑛=23) or Open thoracotomy (𝑛=20) over an 8-month period. Blood samples were collected preoperatively and postoperatively on days (POD) 1 and 3 for enzyme linked immunosorbent assay determination of angiogenic factors. Results. Patient demographics were comparable. For all patients undergoing major lung resection, postoperative Ang-1 and sVEGFR2 levels were significantly decreased, while Ang-2 and sVEGFR1 levels markedly increased. No significant peri-operative changes in VEGF levels were observed. Compared with open group, VATS had significantly lower plasma levels of VEGF (VATS 170±93 pg/mL; Open 486±641 pg/mL; 𝑃=0.04) and Ang-2 (VATS 2484±1119 pg/mL; Open 3379±1287 pg/mL; 𝑃=0.026) on POD3. Conclusions. Major lung resection for early stage NSCLC leads to a pro-angiogenic status, with increased Ang-2 and decreased Ang-1 productions. VATS is associated with an attenuated angiogenic response with lower circulating VEGF and Ang-2 levels compared with open. Such differences in angiogenic factors may be important in lung cancer biology and recurrence following surgery. |
| format | Article |
| id | doaj-art-16dc6b4848cb4ccc857abb40fdcb79ae |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-16dc6b4848cb4ccc857abb40fdcb79ae2025-02-03T07:23:55ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/636754636754Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open AccessCalvin S. H. Ng0Song Wan1Randolph H. L. Wong2Anthony M. H. Ho3Anthony P. C. Yim4Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong KongDepartment of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong KongDepartment of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong KongDepartment of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong KongDepartment of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong KongBackground. Angiogenic factors following oncological surgery is important in tumor recurrence. Vascular endothelial growth factor (VEGF), angiopoietin 1 (Ang-1), Ang-2, soluble VEGF-receptor 1 (sVEGFR1) and sVEGFR2 may influence angiogenesis. This prospective study examined the influence of open and video-assisted thoracic surgery (VATS) lung resections for early stage non-small cell lung cancer (NSCLC) on postoperative circulating angiogenic factors. Methods. Forty-three consecutive patients underwent major lung resection through either VATS (𝑛=23) or Open thoracotomy (𝑛=20) over an 8-month period. Blood samples were collected preoperatively and postoperatively on days (POD) 1 and 3 for enzyme linked immunosorbent assay determination of angiogenic factors. Results. Patient demographics were comparable. For all patients undergoing major lung resection, postoperative Ang-1 and sVEGFR2 levels were significantly decreased, while Ang-2 and sVEGFR1 levels markedly increased. No significant peri-operative changes in VEGF levels were observed. Compared with open group, VATS had significantly lower plasma levels of VEGF (VATS 170±93 pg/mL; Open 486±641 pg/mL; 𝑃=0.04) and Ang-2 (VATS 2484±1119 pg/mL; Open 3379±1287 pg/mL; 𝑃=0.026) on POD3. Conclusions. Major lung resection for early stage NSCLC leads to a pro-angiogenic status, with increased Ang-2 and decreased Ang-1 productions. VATS is associated with an attenuated angiogenic response with lower circulating VEGF and Ang-2 levels compared with open. Such differences in angiogenic factors may be important in lung cancer biology and recurrence following surgery.http://dx.doi.org/10.1100/2012/636754 |
| spellingShingle | Calvin S. H. Ng Song Wan Randolph H. L. Wong Anthony M. H. Ho Anthony P. C. Yim Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access The Scientific World Journal |
| title | Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access |
| title_full | Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access |
| title_fullStr | Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access |
| title_full_unstemmed | Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access |
| title_short | Angiogenic Response to Major Lung Resection for Non-Small Cell Lung Cancer with Video-Assisted Thoracic Surgical and Open Access |
| title_sort | angiogenic response to major lung resection for non small cell lung cancer with video assisted thoracic surgical and open access |
| url | http://dx.doi.org/10.1100/2012/636754 |
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