Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract
Introduction: Staphylococcus aureus is one of the first bacteria colonizing in cystic fibrosis (CF) respiratory tract and different virulence factors are responsible for disease progression. It is not clear if CF S. aureus strains are more virulent than strains isolated from non-CF patients. Method...
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The Journal of Infection in Developing Countries
2013-11-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/4135 |
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| author | Nilufer Cakir Aktas Zayre Erturan Onur Karatuna Aysegul Karahasan Yagci |
| author_facet | Nilufer Cakir Aktas Zayre Erturan Onur Karatuna Aysegul Karahasan Yagci |
| author_sort | Nilufer Cakir Aktas |
| collection | DOAJ |
| description | Introduction: Staphylococcus aureus is one of the first bacteria colonizing in cystic fibrosis (CF) respiratory tract and different virulence factors are responsible for disease progression. It is not clear if CF S. aureus strains are more virulent than strains isolated from non-CF patients.
Methodology: Biofilm production was detected by a modified tissue culture plate method, presence of genes encoding for Panton-Valentine leukocidin (PVL) was investigated by a signal amplified sandwich hybridization assay and antimicrobial susceptibility patterns were detected by disk diffusion method.
Results: Staphylococcus aureus clinical isolates (n = 88) recovered from respiratory tract specimens in which 31 of them were from cystic fibrosis (CF) patients were analysed. Biofilm production was detected in 96.8% of CF isolates in which 32.3% exhibited strong positive phenotype and in 47.4% of non-CF isolates in which strong positive phenotype was not observed (p < 0.05). All CF isolates were methicillin susceptible, whereas 53.4% of non-CF isolates (n = 31) were methicillin resistant. No resistance was observed for vancomycin, chloramphenicol and trimethoprim/sulfamethoxazole in any of the isolates. PVL genes were detected only in two isolates (2.3%), one from each group, CF and non-CF, which both were methicillin susceptible
Conclusion: Biofilm rather than PVL production appears to be an important virulence factor in CF patients.
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| format | Article |
| id | doaj-art-16db8eb61a464690aeff3e1fa0f25383 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2013-11-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-16db8eb61a464690aeff3e1fa0f253832025-08-20T02:27:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802013-11-0171110.3855/jidc.4135Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tractNilufer Cakir Aktas0Zayre Erturan1Onur Karatuna2Aysegul Karahasan Yagci3Marmara University, School of Medicine, Istanbul, TurkeyIstanbul University, School of Medicine, Istanbul, TurkeyMarmara University, School of Medicine, Istanbul, TurkeyMarmara University, School of Medicine, Istanbul, TurkeyIntroduction: Staphylococcus aureus is one of the first bacteria colonizing in cystic fibrosis (CF) respiratory tract and different virulence factors are responsible for disease progression. It is not clear if CF S. aureus strains are more virulent than strains isolated from non-CF patients. Methodology: Biofilm production was detected by a modified tissue culture plate method, presence of genes encoding for Panton-Valentine leukocidin (PVL) was investigated by a signal amplified sandwich hybridization assay and antimicrobial susceptibility patterns were detected by disk diffusion method. Results: Staphylococcus aureus clinical isolates (n = 88) recovered from respiratory tract specimens in which 31 of them were from cystic fibrosis (CF) patients were analysed. Biofilm production was detected in 96.8% of CF isolates in which 32.3% exhibited strong positive phenotype and in 47.4% of non-CF isolates in which strong positive phenotype was not observed (p < 0.05). All CF isolates were methicillin susceptible, whereas 53.4% of non-CF isolates (n = 31) were methicillin resistant. No resistance was observed for vancomycin, chloramphenicol and trimethoprim/sulfamethoxazole in any of the isolates. PVL genes were detected only in two isolates (2.3%), one from each group, CF and non-CF, which both were methicillin susceptible Conclusion: Biofilm rather than PVL production appears to be an important virulence factor in CF patients. https://jidc.org/index.php/journal/article/view/4135Cystic fibrosisPanton-Valentine leukocidinantimicrobialbiofilm |
| spellingShingle | Nilufer Cakir Aktas Zayre Erturan Onur Karatuna Aysegul Karahasan Yagci Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract Journal of Infection in Developing Countries Cystic fibrosis Panton-Valentine leukocidin antimicrobial biofilm |
| title | Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract |
| title_full | Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract |
| title_fullStr | Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract |
| title_full_unstemmed | Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract |
| title_short | Panton-Valentine leukocidin and biofilm production of Staphylococcus aureus isolated from respiratory tract |
| title_sort | panton valentine leukocidin and biofilm production of staphylococcus aureus isolated from respiratory tract |
| topic | Cystic fibrosis Panton-Valentine leukocidin antimicrobial biofilm |
| url | https://jidc.org/index.php/journal/article/view/4135 |
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