Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds
This work employs image and numerical analyses of SEM micrographs to understand the fate of partially crystallized S53P4 scaffolds after implantation in rabbit femurs for 2, 4, and 8 weeks. Bioactive glasses commonly used for the regeneration of bone tissue may crystallize during hot-working, which...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Open Ceramics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666539525000240 |
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| _version_ | 1850222527600656384 |
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| author | Laura Aalto-Setälä Gustav Strömberg Peter Uppstu Robert Björkenheim Jukka Pajarinen Nina Lindfors Leena Hupa |
| author_facet | Laura Aalto-Setälä Gustav Strömberg Peter Uppstu Robert Björkenheim Jukka Pajarinen Nina Lindfors Leena Hupa |
| author_sort | Laura Aalto-Setälä |
| collection | DOAJ |
| description | This work employs image and numerical analyses of SEM micrographs to understand the fate of partially crystallized S53P4 scaffolds after implantation in rabbit femurs for 2, 4, and 8 weeks. Bioactive glasses commonly used for the regeneration of bone tissue may crystallize during hot-working, which affects their dissolution. The in vivo degradation behavior of the scaffolds was analyzed from cross-sectional SEM images by separating surface reaction layers, unreacted glass, and ingrown bone. The partial crystallization resulted in scaffolds degrading rapidly without decreasing size, thus enabling image analysis to estimate the progress of the in vivo behavior. The analysis enabled numerical estimates for the dissolution of sodium and silicon from the glass scaffolds. After 56 days, 68 % of silicon and 90 % of sodium had dissolved from the original sintered scaffolds. It was estimated that if the degradation continued similarly, all sodium would dissolve within three months and silicon in eight months. |
| format | Article |
| id | doaj-art-16db22fc8c454e07aed8264b8ac12e38 |
| institution | OA Journals |
| issn | 2666-5395 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Open Ceramics |
| spelling | doaj-art-16db22fc8c454e07aed8264b8ac12e382025-08-20T02:06:19ZengElsevierOpen Ceramics2666-53952025-06-012210075710.1016/j.oceram.2025.100757Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffoldsLaura Aalto-Setälä0Gustav Strömberg1Peter Uppstu2Robert Björkenheim3Jukka Pajarinen4Nina Lindfors5Leena Hupa6Johan Gadolin Process Chemistry Centre, Åbo Akademi University, Turku, FinlandHelsinki University, Helsinki, FinlandPolymer Technology, Faculty of Science and Engineering, Åbo Akademi University, Turku, FinlandDepartment of Musculoskeletal and Plastic Surgery, Helsinki University Hospital, Helsinki University, Helsinki, FinlandPolymer Technology, Faculty of Science and Engineering, Åbo Akademi University, Turku, FinlandDepartment of Musculoskeletal and Plastic Surgery, Helsinki University Hospital, Helsinki University, Helsinki, FinlandJohan Gadolin Process Chemistry Centre, Åbo Akademi University, Turku, Finland; Corresponding author.This work employs image and numerical analyses of SEM micrographs to understand the fate of partially crystallized S53P4 scaffolds after implantation in rabbit femurs for 2, 4, and 8 weeks. Bioactive glasses commonly used for the regeneration of bone tissue may crystallize during hot-working, which affects their dissolution. The in vivo degradation behavior of the scaffolds was analyzed from cross-sectional SEM images by separating surface reaction layers, unreacted glass, and ingrown bone. The partial crystallization resulted in scaffolds degrading rapidly without decreasing size, thus enabling image analysis to estimate the progress of the in vivo behavior. The analysis enabled numerical estimates for the dissolution of sodium and silicon from the glass scaffolds. After 56 days, 68 % of silicon and 90 % of sodium had dissolved from the original sintered scaffolds. It was estimated that if the degradation continued similarly, all sodium would dissolve within three months and silicon in eight months.http://www.sciencedirect.com/science/article/pii/S2666539525000240Bioactive glassIn vivoNumerical analysis |
| spellingShingle | Laura Aalto-Setälä Gustav Strömberg Peter Uppstu Robert Björkenheim Jukka Pajarinen Nina Lindfors Leena Hupa Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds Open Ceramics Bioactive glass In vivo Numerical analysis |
| title | Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds |
| title_full | Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds |
| title_fullStr | Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds |
| title_full_unstemmed | Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds |
| title_short | Image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass S53P4 scaffolds |
| title_sort | image and numerical analyses for understanding the in vivo dissolution of partially crystalline bioactive glass s53p4 scaffolds |
| topic | Bioactive glass In vivo Numerical analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666539525000240 |
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