The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis
The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased sig...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/494783 |
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| author | Shaohua Chen Lixiong Ying Mei Kong Yu Zhang Youming Li |
| author_facet | Shaohua Chen Lixiong Ying Mei Kong Yu Zhang Youming Li |
| author_sort | Shaohua Chen |
| collection | DOAJ |
| description | The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous inflammatory activity. The intestinal metaplasia and dysplasia positivity markedly increased as the degree of gastric atrophy increased. In conclusion, the incidence of H. pylori infection decreased with age and correlated significantly with inflammatory activity in atrophic gastritis patients. The intestinal metaplasia and dysplasia positivity notably increased as the degree of gastric atrophy increased. Large population-based prospective studies are needed to better understand the progression of CAG. |
| format | Article |
| id | doaj-art-16d9ae0fdae64acab374e16896d52497 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-16d9ae0fdae64acab374e16896d524972025-02-03T00:59:16ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/494783494783The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic GastritisShaohua Chen0Lixiong Ying1Mei Kong2Yu Zhang3Youming Li4Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, ChinaDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaDepartment of Oncology, Zhejiang Hospital, Hangzhou 310012, ChinaDepartment of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, ChinaThe clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous inflammatory activity. The intestinal metaplasia and dysplasia positivity markedly increased as the degree of gastric atrophy increased. In conclusion, the incidence of H. pylori infection decreased with age and correlated significantly with inflammatory activity in atrophic gastritis patients. The intestinal metaplasia and dysplasia positivity notably increased as the degree of gastric atrophy increased. Large population-based prospective studies are needed to better understand the progression of CAG.http://dx.doi.org/10.1155/2013/494783 |
| spellingShingle | Shaohua Chen Lixiong Ying Mei Kong Yu Zhang Youming Li The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis Gastroenterology Research and Practice |
| title | The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis |
| title_full | The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis |
| title_fullStr | The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis |
| title_full_unstemmed | The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis |
| title_short | The Prevalence of Helicobacter pylori Infection Decreases with Older Age in Atrophic Gastritis |
| title_sort | prevalence of helicobacter pylori infection decreases with older age in atrophic gastritis |
| url | http://dx.doi.org/10.1155/2013/494783 |
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