Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus
The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restr...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2003-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629350310001619735 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832568336751263744 |
|---|---|
| author | Jolanta Dorota Torzecka Joanna Narbutt Anna Sysa-jedrzejowska Maciej Borowiec Anetta Ptasinska Grzegorz Woszczek Marek L. Kowalski |
| author_facet | Jolanta Dorota Torzecka Joanna Narbutt Anna Sysa-jedrzejowska Maciej Borowiec Anetta Ptasinska Grzegorz Woszczek Marek L. Kowalski |
| author_sort | Jolanta Dorota Torzecka |
| collection | DOAJ |
| description | The aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA-DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls. |
| format | Article |
| id | doaj-art-16d11a236d134195be1d3aa7bfa63b78 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-16d11a236d134195be1d3aa7bfa63b782025-02-03T00:59:16ZengWileyMediators of Inflammation0962-93511466-18612003-01-0112530330710.1080/09629350310001619735Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigusJolanta Dorota Torzecka0Joanna Narbutt1Anna Sysa-jedrzejowska2Maciej Borowiec3Anetta Ptasinska4Grzegorz Woszczek5Marek L. Kowalski6Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandDepartment of Clinical Immunology and Allergy, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, PolandThe aim of our study was to analyse a significance of tumour necrosis factor (TNF)-α promoter gene polymorphisms in relation to the HLA-DR locus in genetic predisposition to pemphigus. TNF-α gene polymorphisms in position -238 and -308 were identified using a modified polymerase chain reaction-restriction fragment length polymorphism method in 53 patients with pemphigus (38 with pemphigus vulgaris, 15 with pemphigus foliaceus) and 87 healthy controls. The HLA-DRB1 locus was typed using the polymerase chain reaction SSO method in all the patients and 152 population controls.http://dx.doi.org/10.1080/09629350310001619735 |
| spellingShingle | Jolanta Dorota Torzecka Joanna Narbutt Anna Sysa-jedrzejowska Maciej Borowiec Anetta Ptasinska Grzegorz Woszczek Marek L. Kowalski Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus Mediators of Inflammation |
| title | Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus |
| title_full | Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus |
| title_fullStr | Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus |
| title_full_unstemmed | Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus |
| title_short | Tumour necrosis factor-α polymorphism as one of the complex inherited factors in pemphigus |
| title_sort | tumour necrosis factor α polymorphism as one of the complex inherited factors in pemphigus |
| url | http://dx.doi.org/10.1080/09629350310001619735 |
| work_keys_str_mv | AT jolantadorotatorzecka tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT joannanarbutt tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT annasysajedrzejowska tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT maciejborowiec tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT anettaptasinska tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT grzegorzwoszczek tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus AT mareklkowalski tumournecrosisfactorapolymorphismasoneofthecomplexinheritedfactorsinpemphigus |