An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma
Introduction. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare disease entity associated with textured breast implants. Though the clinical course is typically indolent, BIA-ALCL can occasionally invade through the capsule into the breast parenchyma with spread to the re...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2022/4700787 |
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| author | Sarah Premji Andreia Barbieri Christine Roth Eric M. Rohren Gustavo Rivero Sravanti P Teegavarapu |
| author_facet | Sarah Premji Andreia Barbieri Christine Roth Eric M. Rohren Gustavo Rivero Sravanti P Teegavarapu |
| author_sort | Sarah Premji |
| collection | DOAJ |
| description | Introduction. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare disease entity associated with textured breast implants. Though the clinical course is typically indolent, BIA-ALCL can occasionally invade through the capsule into the breast parenchyma with spread to the regional lymph nodes and beyond including chest wall invasive disease. Case. We present the case of a 51-year-old female with a history of bilateral silicone breast implants placed approximately twenty years ago who presented with two months of progressively enlarging right breast mass. Ultrasound-guided biopsy of right breast mass and right axillary lymph node showed CD 30-positive ALK-negative anaplastic large cell lymphoma, and staging work up showed extension of the tumor to chest wall and ribs consistent with advanced disease. She received CHP-BV (cyclophosphamide, doxorubicin, prednisone, and brentuximab vedotin) for six cycles with complete metabolic response. This was followed by extensive surgical extirpation and reconstruction, radiation for residual disease and consolidation with autologous stem cell transplant. She is currently on maintenance brentuximab vedotin with no evidence of active disease post autologous stem cell transplant. Conclusion. Treatment guidelines for advanced chest wall invasive BIA-ALCL are not well defined. Lack of predictive factors warrants mutation analysis and genetic sequencing to identify those at highest risk of progression to chest wall invasive disease. This rare case highlights the need for definitive consensus on the optimal management of chest wall invasive BIA-ALCL. |
| format | Article |
| id | doaj-art-16c6e7c4860f411f815f0fdda0cd0cdd |
| institution | OA Journals |
| issn | 2090-6579 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-16c6e7c4860f411f815f0fdda0cd0cdd2025-08-20T02:02:36ZengWileyCase Reports in Hematology2090-65792022-01-01202210.1155/2022/4700787An Unusual Case of Breast Implant-Associated Anaplastic Large Cell LymphomaSarah Premji0Andreia Barbieri1Christine Roth2Eric M. Rohren3Gustavo Rivero4Sravanti P Teegavarapu5Department of MedicineDepartment of Pathology and ImmunologyDepartment of Pathology and ImmunologyDepartment of RadiologyDepartment of MedicineDepartment of MedicineIntroduction. Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare disease entity associated with textured breast implants. Though the clinical course is typically indolent, BIA-ALCL can occasionally invade through the capsule into the breast parenchyma with spread to the regional lymph nodes and beyond including chest wall invasive disease. Case. We present the case of a 51-year-old female with a history of bilateral silicone breast implants placed approximately twenty years ago who presented with two months of progressively enlarging right breast mass. Ultrasound-guided biopsy of right breast mass and right axillary lymph node showed CD 30-positive ALK-negative anaplastic large cell lymphoma, and staging work up showed extension of the tumor to chest wall and ribs consistent with advanced disease. She received CHP-BV (cyclophosphamide, doxorubicin, prednisone, and brentuximab vedotin) for six cycles with complete metabolic response. This was followed by extensive surgical extirpation and reconstruction, radiation for residual disease and consolidation with autologous stem cell transplant. She is currently on maintenance brentuximab vedotin with no evidence of active disease post autologous stem cell transplant. Conclusion. Treatment guidelines for advanced chest wall invasive BIA-ALCL are not well defined. Lack of predictive factors warrants mutation analysis and genetic sequencing to identify those at highest risk of progression to chest wall invasive disease. This rare case highlights the need for definitive consensus on the optimal management of chest wall invasive BIA-ALCL.http://dx.doi.org/10.1155/2022/4700787 |
| spellingShingle | Sarah Premji Andreia Barbieri Christine Roth Eric M. Rohren Gustavo Rivero Sravanti P Teegavarapu An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma Case Reports in Hematology |
| title | An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma |
| title_full | An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma |
| title_fullStr | An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma |
| title_full_unstemmed | An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma |
| title_short | An Unusual Case of Breast Implant-Associated Anaplastic Large Cell Lymphoma |
| title_sort | unusual case of breast implant associated anaplastic large cell lymphoma |
| url | http://dx.doi.org/10.1155/2022/4700787 |
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