Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation

Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation

IntroductionDrug-induced cardiotoxicity (DICT), defined as myocardial injury caused by direct or indirect toxicity of therapeutic agents, disrupts cardiovascular homeostasis, underscoring the urgent need for preventive strategies in clinical practice. Doxorubicin (DOX), a clinically established anth...

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Bibliographic Details
Main Authors:	Yixiao Yan, Mingzhen Fang, Cong Zhao, Xinru Lin, Chen Tong, Cheng Xiang, Ya Ran, Xuelian Wang, Shuixin Li, Gaozhi Chen, Lili Fu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Pharmacology
Subjects:	drug-induced cardiotoxicity (DICT) doxorubicin (DOX) nuclear factor erythroid 2-related factor 2 (Nrf2) Dl-3-n-butylphthalide (NBP) kelch-like ECH associated protein-1 (Keap1) C57BL/6 mice
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1542296/full
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