Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents
Metabolic syndrome is a medical disorder characterized by obesity, hyperglycemia, dyslipidemia, and hypertension. Thyroid hormone has been shown to affect many metabolic processes. This study was undertaken to explore the relationship between serum thyrotropin and components of metabolic syndrome in...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/289503 |
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| author | Jingfan Zhang Ranhua Jiang Ling Li Ping Li Xue Li Zinan Wang Liang Li Weiping Teng |
| author_facet | Jingfan Zhang Ranhua Jiang Ling Li Ping Li Xue Li Zinan Wang Liang Li Weiping Teng |
| author_sort | Jingfan Zhang |
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| description | Metabolic syndrome is a medical disorder characterized by obesity, hyperglycemia, dyslipidemia, and hypertension. Thyroid hormone has been shown to affect many metabolic processes. This study was undertaken to explore the relationship between serum thyrotropin and components of metabolic syndrome in Chinese adolescents. Waist circumference (76.4 ± 10.7 versus 70.0 ± 10.6 cm, P = 0.006) and body mass index (23.90 ± 4.20 versus 21.51 ± 4.16 kg/m2, P = 0.011) were significantly greater among adolescents with subclinical hypothyroidism compared with euthyroid subjects. The risk of obesity in the subclinical hypothyroid group was 3.444 times that in the euthyroid group (odds ratio = 3.444, 95% confidence interval (CI): 1.570–7.553). Serum TSH was significantly positively correlated with waist circumference (β = 1.512, P = 0.019), TC (β = 0.160, P = 0.003), LDL-C (β = 0.032, P = 0.008), and TG (β = 0.095, P = 0.001). The TSH level in the metabolic syndrome group was significantly higher than that in nonmetabolic syndrome group (2.65 [2.28–3.80] versus 2.53 [1.92–3.45] mIU/L, P = 0.032). Serum TSH within the reference range was positively associated with TC (β = 0.173, P = 0.013), LDL-C (β = 0.031, P = 0.043), and TG (β = 0.132, P = 0.021). Increased serum TSH in adolescents may be a potential risk factor for metabolic syndrome. |
| format | Article |
| id | doaj-art-16c2b34a5c3e4432a90274aa6834a9a6 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-16c2b34a5c3e4432a90274aa6834a9a62025-02-03T06:08:30ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/289503289503Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese AdolescentsJingfan Zhang0Ranhua Jiang1Ling Li2Ping Li3Xue Li4Zinan Wang5Liang Li6Weiping Teng7Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, ChinaLiaoyang Diabetes Hospital, Liaoyang, Liaoning 111000, ChinaDepartment of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, ChinaDepartment of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, ChinaLiaoyang Diabetes Hospital, Liaoyang, Liaoning 111000, ChinaDepartment of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, ChinaDepartment of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, ChinaLiaoning Province Key Laboratory of Endocrine Diseases, Shenyang 110001, ChinaMetabolic syndrome is a medical disorder characterized by obesity, hyperglycemia, dyslipidemia, and hypertension. Thyroid hormone has been shown to affect many metabolic processes. This study was undertaken to explore the relationship between serum thyrotropin and components of metabolic syndrome in Chinese adolescents. Waist circumference (76.4 ± 10.7 versus 70.0 ± 10.6 cm, P = 0.006) and body mass index (23.90 ± 4.20 versus 21.51 ± 4.16 kg/m2, P = 0.011) were significantly greater among adolescents with subclinical hypothyroidism compared with euthyroid subjects. The risk of obesity in the subclinical hypothyroid group was 3.444 times that in the euthyroid group (odds ratio = 3.444, 95% confidence interval (CI): 1.570–7.553). Serum TSH was significantly positively correlated with waist circumference (β = 1.512, P = 0.019), TC (β = 0.160, P = 0.003), LDL-C (β = 0.032, P = 0.008), and TG (β = 0.095, P = 0.001). The TSH level in the metabolic syndrome group was significantly higher than that in nonmetabolic syndrome group (2.65 [2.28–3.80] versus 2.53 [1.92–3.45] mIU/L, P = 0.032). Serum TSH within the reference range was positively associated with TC (β = 0.173, P = 0.013), LDL-C (β = 0.031, P = 0.043), and TG (β = 0.132, P = 0.021). Increased serum TSH in adolescents may be a potential risk factor for metabolic syndrome.http://dx.doi.org/10.1155/2014/289503 |
| spellingShingle | Jingfan Zhang Ranhua Jiang Ling Li Ping Li Xue Li Zinan Wang Liang Li Weiping Teng Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents International Journal of Endocrinology |
| title | Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents |
| title_full | Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents |
| title_fullStr | Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents |
| title_full_unstemmed | Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents |
| title_short | Serum Thyrotropin Is Positively Correlated with the Metabolic Syndrome Components of Obesity and Dyslipidemia in Chinese Adolescents |
| title_sort | serum thyrotropin is positively correlated with the metabolic syndrome components of obesity and dyslipidemia in chinese adolescents |
| url | http://dx.doi.org/10.1155/2014/289503 |
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