Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection?
Purpose of the study. To reveal the relationship between the serum concentration of vascular endothelial growth factor and the structural and functional state of the myocardium in patients in the post-infarction period at the stage of rehabilitation.Materials and methods. We examined 94 patients at...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Private institution educational organization of higher education "Medical University "ReaViz"
2023-07-01
|
| Series: | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| Subjects: | |
| Online Access: | https://vestnik.reaviz.ru/jour/article/view/722 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850050442205069312 |
|---|---|
| author | A. M. Vorob'ev V. I. Ruzov A. S. Salmin M. A. Mel'nikova |
| author_facet | A. M. Vorob'ev V. I. Ruzov A. S. Salmin M. A. Mel'nikova |
| author_sort | A. M. Vorob'ev |
| collection | DOAJ |
| description | Purpose of the study. To reveal the relationship between the serum concentration of vascular endothelial growth factor and the structural and functional state of the myocardium in patients in the post-infarction period at the stage of rehabilitation.Materials and methods. We examined 94 patients at the outpatient stage of rehabilitation after ad hoc stenting 6 weeks after myocardial infarction, 10 healthy volunteers without somatic pathology. All participants in the study underwent standard transthoracic echocardiography with assessment of thickness of epicardial fat, assessment of the concentration of vascular endothelial growth factor (VEGF) in peripheral blood by ELISA.Results and discussion. VEGF values above the median values were associated with lower left ventricular ejection fraction and left ventricular fraction shortening, which indirectly may indicate a more pronounced expression of VEGF in patients with left ventricular systolic dysfunction. Assessing the parameters of LV diastolic dysfunction in groups with different levels of VEGF, no significant differences were found in patients after myocardial infarction. Correlation relationships between the content of VEGF and the thickness of epicardial adipose tissue were not found either among patients or in the control group.Conclusions. Elevated VEGF values in patients with coronary artery disease at the 6th week of rehabilitation were accompanied by left ventricle systolic dysfunction, in contrast to diastolic dysfunction. There was no direct correlation between the thickness of epicardial fat and the concentration of VEGF in the blood serum in patients with coronary artery disease. |
| format | Article |
| id | doaj-art-16b4b145a4a640a6b8be8db590733602 |
| institution | DOAJ |
| issn | 2226-762X 2782-1579 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | Private institution educational organization of higher education "Medical University "ReaViz" |
| record_format | Article |
| series | Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье |
| spelling | doaj-art-16b4b145a4a640a6b8be8db5907336022025-08-20T02:53:27ZrusPrivate institution educational organization of higher education "Medical University "ReaViz"Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье2226-762X2782-15792023-07-01133889210.20340/vmi-rvz.2023.3.CLIN.10446Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection?A. M. Vorob'ev0V. I. Ruzov1A. S. Salmin2M. A. Mel'nikova3Central City Clinical HospitalUlyanovsk State University, Institute of Medicine, Ecology and Physical EducationReginal Clinical Hospital of UlyanovskCentral City Clinical HospitalPurpose of the study. To reveal the relationship between the serum concentration of vascular endothelial growth factor and the structural and functional state of the myocardium in patients in the post-infarction period at the stage of rehabilitation.Materials and methods. We examined 94 patients at the outpatient stage of rehabilitation after ad hoc stenting 6 weeks after myocardial infarction, 10 healthy volunteers without somatic pathology. All participants in the study underwent standard transthoracic echocardiography with assessment of thickness of epicardial fat, assessment of the concentration of vascular endothelial growth factor (VEGF) in peripheral blood by ELISA.Results and discussion. VEGF values above the median values were associated with lower left ventricular ejection fraction and left ventricular fraction shortening, which indirectly may indicate a more pronounced expression of VEGF in patients with left ventricular systolic dysfunction. Assessing the parameters of LV diastolic dysfunction in groups with different levels of VEGF, no significant differences were found in patients after myocardial infarction. Correlation relationships between the content of VEGF and the thickness of epicardial adipose tissue were not found either among patients or in the control group.Conclusions. Elevated VEGF values in patients with coronary artery disease at the 6th week of rehabilitation were accompanied by left ventricle systolic dysfunction, in contrast to diastolic dysfunction. There was no direct correlation between the thickness of epicardial fat and the concentration of VEGF in the blood serum in patients with coronary artery disease.https://vestnik.reaviz.ru/jour/article/view/722postinfarction statevascular endothelial growth factorvegfepicardial fat |
| spellingShingle | A. M. Vorob'ev V. I. Ruzov A. S. Salmin M. A. Mel'nikova Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье postinfarction state vascular endothelial growth factor vegf epicardial fat |
| title | Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? |
| title_full | Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? |
| title_fullStr | Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? |
| title_full_unstemmed | Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? |
| title_short | Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? |
| title_sort | structural and functional state of postinfarction myocardium and vascular endothelial growth factor is there a connection |
| topic | postinfarction state vascular endothelial growth factor vegf epicardial fat |
| url | https://vestnik.reaviz.ru/jour/article/view/722 |
| work_keys_str_mv | AT amvorobev structuralandfunctionalstateofpostinfarctionmyocardiumandvascularendothelialgrowthfactoristhereaconnection AT viruzov structuralandfunctionalstateofpostinfarctionmyocardiumandvascularendothelialgrowthfactoristhereaconnection AT assalmin structuralandfunctionalstateofpostinfarctionmyocardiumandvascularendothelialgrowthfactoristhereaconnection AT mamelnikova structuralandfunctionalstateofpostinfarctionmyocardiumandvascularendothelialgrowthfactoristhereaconnection |