Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice
The protective activity of Ingavirin® against experimental infection caused by influenza B virus was studied on albino mice vs. Arbidol®. Oral use of Ingavirin® was shown to decrease the infectious titers of the virus in the animal lung tissue, to normalize the body weight dynamics, to lower the mor...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/292 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850063458592096256 |
|---|---|
| author | V. V. Zarubaev A. V. Garshinina N. A. Kalinina A. A. Shtro V. E. Nebolsin O. I. Kiselev |
| author_facet | V. V. Zarubaev A. V. Garshinina N. A. Kalinina A. A. Shtro V. E. Nebolsin O. I. Kiselev |
| author_sort | V. V. Zarubaev |
| collection | DOAJ |
| description | The protective activity of Ingavirin® against experimental infection caused by influenza B virus was studied on albino mice vs. Arbidol®. Oral use of Ingavirin® was shown to decrease the infectious titers of the virus in the animal lung tissue, to normalize the body weight dynamics, to lower the mortality and to increase the average lifespan vs. the placebo-treated animals. The activity of Ingavirin® was higher than that of the reference drug. The results allowed to consider Ingavirin® as a prospective agent for the treatment of influenza infection in humans. |
| format | Article |
| id | doaj-art-16b4294b7db64f0cb2a1856d174b9b15 |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-16b4294b7db64f0cb2a1856d174b9b152025-08-20T02:49:35ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01553-4811291Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino MiceV. V. Zarubaev0A. V. Garshinina1N. A. Kalinina2A. A. Shtro3V. E. Nebolsin4O. I. Kiselev5Research Institute of Influenza, North-West Branch of the Russian Academy of Medical Sciences, St. PetersburgResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical Sciences, St. PetersburgResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical Sciences, St. PetersburgResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical Sciences, St. PetersburgJSC Valenta Pharm Co., MoscowResearch Institute of Influenza, North-West Branch of the Russian Academy of Medical Sciences, St. PetersburgThe protective activity of Ingavirin® against experimental infection caused by influenza B virus was studied on albino mice vs. Arbidol®. Oral use of Ingavirin® was shown to decrease the infectious titers of the virus in the animal lung tissue, to normalize the body weight dynamics, to lower the mortality and to increase the average lifespan vs. the placebo-treated animals. The activity of Ingavirin® was higher than that of the reference drug. The results allowed to consider Ingavirin® as a prospective agent for the treatment of influenza infection in humans.https://www.antibiotics-chemotherapy.ru/jour/article/view/292ingavirin®influenzavirus bantiviral chemotherapy |
| spellingShingle | V. V. Zarubaev A. V. Garshinina N. A. Kalinina A. A. Shtro V. E. Nebolsin O. I. Kiselev Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice Антибиотики и Химиотерапия ingavirin® influenza virus b antiviral chemotherapy |
| title | Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice |
| title_full | Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice |
| title_fullStr | Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice |
| title_full_unstemmed | Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice |
| title_short | Antiviral Activity of Ingavirin® in Experimental Lethal Influenza Due to Influenza Virus B in Albino Mice |
| title_sort | antiviral activity of ingavirin r in experimental lethal influenza due to influenza virus b in albino mice |
| topic | ingavirin® influenza virus b antiviral chemotherapy |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/292 |
| work_keys_str_mv | AT vvzarubaev antiviralactivityofingavirininexperimentallethalinfluenzaduetoinfluenzavirusbinalbinomice AT avgarshinina antiviralactivityofingavirininexperimentallethalinfluenzaduetoinfluenzavirusbinalbinomice AT nakalinina antiviralactivityofingavirininexperimentallethalinfluenzaduetoinfluenzavirusbinalbinomice AT aashtro antiviralactivityofingavirininexperimentallethalinfluenzaduetoinfluenzavirusbinalbinomice AT venebolsin antiviralactivityofingavirininexperimentallethalinfluenzaduetoinfluenzavirusbinalbinomice AT oikiselev antiviralactivityofingavirininexperimentallethalinfluenzaduetoinfluenzavirusbinalbinomice |