Basement membrane perforations guide anterior–posterior axis formation

Abstract Establishment of the anterior-posterior (AP) axis is a critical symmetry-breaking event in mammalian development. In mice, this process involves the directed migration of the distal visceral endoderm (DVE). Here, we use targeted perturbations to demonstrate that asymmetric perforations in t...

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Bibliographic Details
Main Authors: Dong-Yuan Chen, Nikolas H. Claussen, Shiny Titus, Wenqi Hu, Bailey A. T. Weatherbee, Rachel S. Mandelbaum, Richard T. Scott Jr, Emre Seli, Sebastian J. Streichan, Magdalena Zernicka-Goetz
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61441-6
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