In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen
The experimental investigation of the Ingavirin® antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
|
| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/247 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850063458101362688 |
|---|---|
| author | S. YA. Loginova S. V. Borisevich V. A. Maksimov V. P. Bondarev V. E. Nebolsin |
| author_facet | S. YA. Loginova S. V. Borisevich V. A. Maksimov V. P. Bondarev V. E. Nebolsin |
| author_sort | S. YA. Loginova |
| collection | DOAJ |
| description | The experimental investigation of the Ingavirin® antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up to 0.001 CPD50/cell), the inhibition of the virus cytopathic effect by Ingavirin® amounted to 100% in all the tested concentrations (including the low ones) added either before or after the culture contamination. Ingavirin® was efficient in inhibition of the adenovirus type 5 reproduction in the HeLa cell culture. |
| format | Article |
| id | doaj-art-16a64503170f47578663eb270efcd24b |
| institution | DOAJ |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-16a64503170f47578663eb270efcd24b2025-08-20T02:49:35ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01547-81618246In vitro Ingavirin® Efficacy Against Adenoviral Infection PathogenS. YA. Loginova0S. V. Borisevich1V. A. Maksimov2V. P. Bondarev3V. E. Nebolsin4Branch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadBranch of Central Research Institute No. 48, Ministry of Defense of the Russian Federation, Virological Centre, Sergiev PosadValenta Farmacevtica, MoscowThe experimental investigation of the Ingavirin® antiviral effect showed that in concentrations of 200 and 100 mcg/ml it totally protected the cells from the cytopathic action of the virus, when added before the inoculation of the HeLa cell culture. After a tenfold decrease of the infective dose (up to 0.001 CPD50/cell), the inhibition of the virus cytopathic effect by Ingavirin® amounted to 100% in all the tested concentrations (including the low ones) added either before or after the culture contamination. Ingavirin® was efficient in inhibition of the adenovirus type 5 reproduction in the HeLa cell culture.https://www.antibiotics-chemotherapy.ru/jour/article/view/247ingavirin®adenoviruscell cultureantiviral effect |
| spellingShingle | S. YA. Loginova S. V. Borisevich V. A. Maksimov V. P. Bondarev V. E. Nebolsin In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen Антибиотики и Химиотерапия ingavirin® adenovirus cell culture antiviral effect |
| title | In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen |
| title_full | In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen |
| title_fullStr | In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen |
| title_full_unstemmed | In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen |
| title_short | In vitro Ingavirin® Efficacy Against Adenoviral Infection Pathogen |
| title_sort | in vitro ingavirin r efficacy against adenoviral infection pathogen |
| topic | ingavirin® adenovirus cell culture antiviral effect |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/247 |
| work_keys_str_mv | AT syaloginova invitroingavirinefficacyagainstadenoviralinfectionpathogen AT svborisevich invitroingavirinefficacyagainstadenoviralinfectionpathogen AT vamaksimov invitroingavirinefficacyagainstadenoviralinfectionpathogen AT vpbondarev invitroingavirinefficacyagainstadenoviralinfectionpathogen AT venebolsin invitroingavirinefficacyagainstadenoviralinfectionpathogen |