Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis
Abstract Obesity is a metabolic disease characterized by an imbalance between caloric intake and expenditure, leading to excess fat and increasing the risk of various health conditions. This study compares the anti-obesity effects of gold nanoparticles (AuNPs) to orlistat in an experimental model of...
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| Format: | Article |
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-87971-z |
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| author | Rana M. Selima Israa A. Saleem Mamdouh M. Shawki Amira A. Darwish Mona A. Yehia Ehab I. Mohamed |
| author_facet | Rana M. Selima Israa A. Saleem Mamdouh M. Shawki Amira A. Darwish Mona A. Yehia Ehab I. Mohamed |
| author_sort | Rana M. Selima |
| collection | DOAJ |
| description | Abstract Obesity is a metabolic disease characterized by an imbalance between caloric intake and expenditure, leading to excess fat and increasing the risk of various health conditions. This study compares the anti-obesity effects of gold nanoparticles (AuNPs) to orlistat in an experimental model of induced obesity in Wistar Albino rats. In addition to negative and positive control rats, obese rats were treated with variable daily and weekly doses of AuNPs and daily orlistat for nine weeks. Bioelectric impedance analysis (BIA) and dissection techniques were used to indirectly and directly measure body-composition in all rat groups. Hepatic and renal function and ultrastructure were assessed by blood biochemical and histological examinations to detect treatment-related alterations. High doses of AuNPs reduced body fat, increased muscle mass, improved dyslipidemia, glycemia, and antioxidant effects in obese rats, and restored normal TG, FBG, and MDA levels by reducing obesity-related oxidative damage. Histological and ultrastructural examinations showed that these high doses repaired liver and kidney cells, and reduced fat accumulation and body weight compared to the standard treatment for obesity by orlistat. |
| format | Article |
| id | doaj-art-169ee2b26aef45a989505cc2c90fd990 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-169ee2b26aef45a989505cc2c90fd9902025-08-20T03:00:58ZengNature PortfolioScientific Reports2045-23222025-02-0115111710.1038/s41598-025-87971-zEffect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysisRana M. Selima0Israa A. Saleem1Mamdouh M. Shawki2Amira A. Darwish3Mona A. Yehia4Ehab I. Mohamed5Medical Biophysics Department, Medical Research Institute, Alexandria UniversityOptometry Department, Technical Medical Institute, Erbil Polytechnic UniversityMedical Biophysics Department, Medical Research Institute, Alexandria UniversityMedical Laboratory Technology Department, Faculty of Applied Health Sciences Technology, Pharos UniversityHistochemistry and Cell Biology Department, Medical Research Institute, Alexandria UniversityMedical Biophysics Department, Medical Research Institute, Alexandria UniversityAbstract Obesity is a metabolic disease characterized by an imbalance between caloric intake and expenditure, leading to excess fat and increasing the risk of various health conditions. This study compares the anti-obesity effects of gold nanoparticles (AuNPs) to orlistat in an experimental model of induced obesity in Wistar Albino rats. In addition to negative and positive control rats, obese rats were treated with variable daily and weekly doses of AuNPs and daily orlistat for nine weeks. Bioelectric impedance analysis (BIA) and dissection techniques were used to indirectly and directly measure body-composition in all rat groups. Hepatic and renal function and ultrastructure were assessed by blood biochemical and histological examinations to detect treatment-related alterations. High doses of AuNPs reduced body fat, increased muscle mass, improved dyslipidemia, glycemia, and antioxidant effects in obese rats, and restored normal TG, FBG, and MDA levels by reducing obesity-related oxidative damage. Histological and ultrastructural examinations showed that these high doses repaired liver and kidney cells, and reduced fat accumulation and body weight compared to the standard treatment for obesity by orlistat.https://doi.org/10.1038/s41598-025-87971-zObesityGold nanoparticles (AuNPs)Body-compositionBioelectric Impedance Analysis (BIA)DyslipidemiasOxidative damage |
| spellingShingle | Rana M. Selima Israa A. Saleem Mamdouh M. Shawki Amira A. Darwish Mona A. Yehia Ehab I. Mohamed Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis Scientific Reports Obesity Gold nanoparticles (AuNPs) Body-composition Bioelectric Impedance Analysis (BIA) Dyslipidemias Oxidative damage |
| title | Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis |
| title_full | Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis |
| title_fullStr | Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis |
| title_full_unstemmed | Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis |
| title_short | Effect of gold nanoparticles treatment on rats-induced obesity by evaluating body-composition directly and indirectly via bioelectric impedance analysis |
| title_sort | effect of gold nanoparticles treatment on rats induced obesity by evaluating body composition directly and indirectly via bioelectric impedance analysis |
| topic | Obesity Gold nanoparticles (AuNPs) Body-composition Bioelectric Impedance Analysis (BIA) Dyslipidemias Oxidative damage |
| url | https://doi.org/10.1038/s41598-025-87971-z |
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