Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women

Introduction: Bacterial vaginosis (BV) is a syndrome related to Gardnerella vaginalis and is characterized by an imbalance in the vaginal microbiota. This work focused on the evaluation of antimicrobial susceptibility patterns and the occurrence of the vaginolysin (vly) gene in G. vaginalis isolated...

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Main Authors: Daniele Maria Knupp de Souza, Claudio Galuppo Diniz, Didier Silveira Castellano Filho, Laura Maria Andrade de Oliveira, Débora Martins Coelho, Luciana de Souza Talha, Thiago César do Nascimento, Alessandra Barbosa Ferreira-Machado, Vânia Lúcia da Silva
Format: Article
Language:English
Published: The Journal of Infection in Developing Countries 2016-09-01
Series:Journal of Infection in Developing Countries
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Online Access:https://jidc.org/index.php/journal/article/view/7161
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author Daniele Maria Knupp de Souza
Claudio Galuppo Diniz
Didier Silveira Castellano Filho
Laura Maria Andrade de Oliveira
Débora Martins Coelho
Luciana de Souza Talha
Thiago César do Nascimento
Alessandra Barbosa Ferreira-Machado
Vânia Lúcia da Silva
author_facet Daniele Maria Knupp de Souza
Claudio Galuppo Diniz
Didier Silveira Castellano Filho
Laura Maria Andrade de Oliveira
Débora Martins Coelho
Luciana de Souza Talha
Thiago César do Nascimento
Alessandra Barbosa Ferreira-Machado
Vânia Lúcia da Silva
author_sort Daniele Maria Knupp de Souza
collection DOAJ
description Introduction: Bacterial vaginosis (BV) is a syndrome related to Gardnerella vaginalis and is characterized by an imbalance in the vaginal microbiota. This work focused on the evaluation of antimicrobial susceptibility patterns and the occurrence of the vaginolysin (vly) gene in G. vaginalis isolated from BV and non-BV patients. Methodology: The vaginal secretions were collected randomly and processed for G. vaginalis isolation. The isolates were presumptively identified by β-hemolysis and oxidase and catalase tests. Polymerase chain reaction (PCR) was performed to confirm bacterial identity and to detect the vly gene. Antimicrobial susceptibility patterns were determined. Results: Of 89 patients, G. vaginalis was isolated from 42 (37 BV and 5 non-BV), and 204 isolates were selected (179 from BV and 25 non-BV). The vly gene was detected in all G. vaginalis isolated from non-BV women and in 98.3% of the bacteria from BV patients. High resistance was observed for ampicillin (54.4%), metronidazole (59.8%), tinidazole (60.3%) and secnidazole (71.6%). Conclusions: Further studies are needed to better address the role of G. vaginalis and the vly gene in BV pathogenesis.
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publisher The Journal of Infection in Developing Countries
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spelling doaj-art-169651dd4c15425bbd82cbb9f4b18c682025-08-20T02:16:06ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802016-09-01100910.3855/jidc.7161Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed womenDaniele Maria Knupp de Souza0Claudio Galuppo Diniz1Didier Silveira Castellano Filho2Laura Maria Andrade de Oliveira3Débora Martins Coelho4Luciana de Souza Talha5Thiago César do Nascimento6Alessandra Barbosa Ferreira-Machado7Vânia Lúcia da Silva8Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFaculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilFederal University of Juiz de Fora, Juiz de Fora, Minas Gerais, BrazilIntroduction: Bacterial vaginosis (BV) is a syndrome related to Gardnerella vaginalis and is characterized by an imbalance in the vaginal microbiota. This work focused on the evaluation of antimicrobial susceptibility patterns and the occurrence of the vaginolysin (vly) gene in G. vaginalis isolated from BV and non-BV patients. Methodology: The vaginal secretions were collected randomly and processed for G. vaginalis isolation. The isolates were presumptively identified by β-hemolysis and oxidase and catalase tests. Polymerase chain reaction (PCR) was performed to confirm bacterial identity and to detect the vly gene. Antimicrobial susceptibility patterns were determined. Results: Of 89 patients, G. vaginalis was isolated from 42 (37 BV and 5 non-BV), and 204 isolates were selected (179 from BV and 25 non-BV). The vly gene was detected in all G. vaginalis isolated from non-BV women and in 98.3% of the bacteria from BV patients. High resistance was observed for ampicillin (54.4%), metronidazole (59.8%), tinidazole (60.3%) and secnidazole (71.6%). Conclusions: Further studies are needed to better address the role of G. vaginalis and the vly gene in BV pathogenesis. https://jidc.org/index.php/journal/article/view/7161bacterial vaginosisGardnerella vaginalisNugent scoreantimicrobial resistanceclue-cells
spellingShingle Daniele Maria Knupp de Souza
Claudio Galuppo Diniz
Didier Silveira Castellano Filho
Laura Maria Andrade de Oliveira
Débora Martins Coelho
Luciana de Souza Talha
Thiago César do Nascimento
Alessandra Barbosa Ferreira-Machado
Vânia Lúcia da Silva
Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
Journal of Infection in Developing Countries
bacterial vaginosis
Gardnerella vaginalis
Nugent score
antimicrobial resistance
clue-cells
title Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
title_full Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
title_fullStr Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
title_full_unstemmed Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
title_short Antimicrobial susceptibility and vaginolysin in Gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
title_sort antimicrobial susceptibility and vaginolysin in gardnerella vaginalis from healthy and bacterial vaginosis diagnosed women
topic bacterial vaginosis
Gardnerella vaginalis
Nugent score
antimicrobial resistance
clue-cells
url https://jidc.org/index.php/journal/article/view/7161
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