Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed curren...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/269076 |
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| author | Mark S Silverberg Jack Satsangi Tariq Ahmad Ian DR Arnott Charles N Bernstein Steven R Brant Renzo Caprilli Jean-Frédéric Colombel Christoph Gasche Karel Geboes Derek P Jewell Amir Karban Edward V Loftus A Salvador Peña Robert H Riddell David B Sachar Stefan Schreiber A Hillary Steinhart Stephan R Targan Severine Vermeire Bryan F Warren |
| author_facet | Mark S Silverberg Jack Satsangi Tariq Ahmad Ian DR Arnott Charles N Bernstein Steven R Brant Renzo Caprilli Jean-Frédéric Colombel Christoph Gasche Karel Geboes Derek P Jewell Amir Karban Edward V Loftus A Salvador Peña Robert H Riddell David B Sachar Stefan Schreiber A Hillary Steinhart Stephan R Targan Severine Vermeire Bryan F Warren |
| author_sort | Mark S Silverberg |
| collection | DOAJ |
| description | The discovery of a series of genetic and serological markers associated
with disease susceptibility and phenotype in inflammatory bowel disease
has led to the prospect of an integrated classification system
involving clinical, serological and genetic parameters. The Working
Party has reviewed current clinical classification systems in Crohn’s
disease, ulcerative colitis and indeterminate colitis, and provided recommendations
for clinical classification in practice. Progress with
respect to integrating serological and genetic markers has been examined
in detail, and the implications are discussed. While an integrated
system is not proposed for clinical use at present, the introduction of a
widely acceptable clinical subclassification is strongly advocated,
which would allow detailed correlations among serotype, genotype and
clinical phenotype to be examined and confirmed in independent
cohorts of patients and, thereby, provide a vital foundation for future
work. |
| format | Article |
| id | doaj-art-168e8fa578624d5da5d8ebf28b2082c4 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-168e8fa578624d5da5d8ebf28b2082c42025-02-03T06:07:52ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-0119Suppl A5A36A10.1155/2005/269076Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of GastroenterologyMark S Silverberg0Jack Satsangi1Tariq Ahmad2Ian DR Arnott3Charles N Bernstein4Steven R Brant5Renzo Caprilli6Jean-Frédéric Colombel7Christoph Gasche8Karel Geboes9Derek P Jewell10Amir Karban11Edward V Loftus12A Salvador Peña13Robert H Riddell14David B Sachar15Stefan Schreiber16A Hillary Steinhart17Stephan R Targan18Severine Vermeire19Bryan F Warren20Department of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, CanadaDepartment of Gastroenterology, Western General Hospital, University of Edinburgh, Edinburgh, UKGastroenterology Unit, University of Oxford, Gibson Laboratories, Radcliffe Infirmary, Oxford, UKDepartment of Gastroenterology, Western General Hospital, University of Edinburgh, Edinburgh, UKDepartment of Medicine, Section of Gastroenterology, University of Manitoba IBD Clinical and Research Centre, Winnipeg, Manitoba, CanadaThe Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, John Hopkins University School of Medicine, and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USADepartment of Clinical Sciences, University of Rome “La Sapienza”, Rome, ItalyDepartment of Hepatogastroenterology and Registre EPIMAD, Hôpital HURIEZ, CH et U Lille, FranceDivision of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, AustriaDepartment of Pathology, University Hospital, Leuven, BelgiumDepartment of Gastroenterology, University of Oxford, Oxford, UKDepartment of Gastroenterology, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, IsraelDivision of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USADepartment of Pathology, VU University Medical Centre, Amsterdam, The NetherlandsDepartment of Pathology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, CanadaMount Sinai School of Medicine, New York, USAInstitute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, GermanyDepartment of Medicine, Mount Sinai Hospital IBD Centre, University of Toronto, Toronto, Ontario, CanadaCedars-Sinai Division of Gastroenterology, Inflammatory Bowel Disease Center and Immunobiology Institute, UCLA School of Medicine, Los Angeles, California, USADivision of Gastroenterology, University Hospital Gasthuisberg, Leuven, BelgiumDepartment of Cellular Pathology, John Radcliffe Hospital, University of Oxford, Oxford, UKThe discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed current clinical classification systems in Crohn’s disease, ulcerative colitis and indeterminate colitis, and provided recommendations for clinical classification in practice. Progress with respect to integrating serological and genetic markers has been examined in detail, and the implications are discussed. While an integrated system is not proposed for clinical use at present, the introduction of a widely acceptable clinical subclassification is strongly advocated, which would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.http://dx.doi.org/10.1155/2005/269076 |
| spellingShingle | Mark S Silverberg Jack Satsangi Tariq Ahmad Ian DR Arnott Charles N Bernstein Steven R Brant Renzo Caprilli Jean-Frédéric Colombel Christoph Gasche Karel Geboes Derek P Jewell Amir Karban Edward V Loftus A Salvador Peña Robert H Riddell David B Sachar Stefan Schreiber A Hillary Steinhart Stephan R Targan Severine Vermeire Bryan F Warren Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology Canadian Journal of Gastroenterology |
| title | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology |
| title_full | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology |
| title_fullStr | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology |
| title_full_unstemmed | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology |
| title_short | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology |
| title_sort | toward an integrated clinical molecular and serological classification of inflammatory bowel disease report of a working party of the 2005 montreal world congress of gastroenterology |
| url | http://dx.doi.org/10.1155/2005/269076 |
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