Repurposing hydrochlorothiazide (HCTZ) for colorectal cancer: a retrospective and single center study

Repurposing hydrochlorothiazide (HCTZ) for colorectal cancer: a retrospective and single center study

BackgroundAnti-hypertensive drugs have been reported to demonstrate anti-inflammatory and anti-angiogenic effects. This study aims to investigate the association between anti-hypertensive drugs and the prognosis of colorectal cancer (CRC) patients.MethodsClinical data of 1134 CRC patients with hyper...

Full description

Saved in:

Bibliographic Details
Main Authors:	Dominic Chi-Chung Foo, Jiaxi Li, Zheng Huang, Siming Sui, Ryan Wai-Yan Sin, Abraham Tak Ka Man, Wai-Lun Law, Lui Ng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Pharmacology
Subjects:	colorectal cancer drug repurposing antihypertensive drugs hydrochlorothiazide basophil prognosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1449062/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hydrochlorothiazide Is America's Most Popular Thiazide, But Should It Be?
by: Peter S. Natov, et al.
Published: (2025-03-01)

Comparative effectiveness of fixed combinations of various ramipril and hydrochlorothiazide doses
by: I. E. Chazova, et al.
Published: (2010-08-01)

Antihypertensive and Target-Organ Protective Properties of Telmisartan and Hydrochlorothiazide Single-Pill Combination
by: O. D. Ostroumova, et al.
Published: (2019-09-01)

FIXED LOW-DOSE COMBINATION OF LISINOPRIL AND HYDROCHLOROTHIAZIDE IN THE PREVENTION OF CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS
by: A. O. Shevchenko, et al.
Published: (2016-01-01)

COMPARATIVE STUDY OF COMBINED DRUGS OF ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE: «RENIPRIL HT» AND «CO-RENITEC» IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION
by: S. Y. Martsevich, et al.
Published: (2015-12-01)

VARIANTS AND PERSPECTIVES OF DRUG REPURPOSING FOR CANCER TREATMENT
by: A. V. Savinkova, et al.
Published: (2018-07-01)

Drug Repurposing for Rare Orphan Diseases Using Machine Learning Techniques
by: Rajesh Manicavasaga, et al.
Published: (2022-05-01)

Literature data-based de novo candidates for drug repurposing
by: Xianglong Liang, et al.
Published: (2025-08-01)

ORGANOPROTECTIVE EFFECTS OF THE FIXED COMBINATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITOR LISINOPRIL AND DIURETIC HYDROCHLOROTHIAZIDE
by: E. A. Ryabikhin, et al.
Published: (2016-01-01)

Antimalarial Drug Repurposing of Epirubicin and Pelitinib in Combination with Artemether and Lumefantrine
by: Douglas O. Ochora, et al.
Published: (2025-06-01)

EVALUATION OF ANTIHYPERTENSIVE THERAPY WITH THE COMBINATION OF OLMESARTAN MEDOXOMIL AND HYDROCHLOROTHIAZIDE
by: Steven G. Chrysant, et al.
Published: (2011-06-01)

REPURPOSING DRUGS FOR CANCER THERAPY
by: Ege Arzuk, et al.
Published: (2022-08-01)

Repurposing Rafoxanide: From Parasite Killer to Cancer Fighter
by: Teresa Pacifico, et al.
Published: (2025-07-01)

FIXED COMBINATION OF RAMIPRIL AND HYDROCHLOROTHIAZIDE: TO WHOM AND WHAT FOR?
by: S. V. Nedogoda
Published: (2016-09-01)

СHOICE OF ZOFENOPRIL AND HYDROCHLOROTHIAZIDE COMBINATION IN THE TREATMENT OF ARTERIAL HYPERTENSION
by: N. A. Dzhaiani
Published: (2016-01-01)

Repurposing of nervous system drugs for cancer treatment: recent advances, challenges, and future perspectives
by: Zixun Wang, et al.
Published: (2025-03-01)

HPLC method with monolithic column for simultaneous determination of irbesartan and hydrochlorothiazide in tablets
by: Alanazi Amer M., et al.
Published: (2014-06-01)

Filling the gap in CNS drug development: evaluation of the role of drug repurposing
by: A. Caban, et al.
Published: (2017-01-01)

Artificial Intelligence-Based Methods for Drug Repurposing and Development in Cancer
by: Sara Herráiz-Gil, et al.
Published: (2025-03-01)

AI-driven drug discovery and repurposing using multi-omics for myocardial infarction and heart failure
by: Ziad Sabry, et al.
Published: (2025-06-01)

Applications of Artificial Intelligence in Drug Repurposing
by: Zhaoman Wan, et al.
Published: (2025-04-01)

DTA Atlas: A massive-scale drug repurposing database
by: Madina Sultanova, et al.
Published: (2024-12-01)

ANTIHYPERTENSIVE TREATMENT WITH COMBINED DRUG OF LOSARTAN AND HYDROCHLOROTHIAZIDE
by: R. M. Linchak, et al.
Published: (2016-01-01)

Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for <i>Trypanosoma cruzi</i> Infection
by: Citlali Vázquez, et al.
Published: (2024-12-01)

Radiation-induced morphea of the breast – characterization and treatment of fibroblast dysfunction with repurposed mesalazine
by: Stephan R. Künzel, et al.
Published: (2024-10-01)

Comparison of Cardiovascular Outcomes Between Chlorthalidone and Hydrochlorothiazide in Hypertensive Patients
by: Subin Lim, et al.
Published: (2025-02-01)

Repurposing Nitazoxanide for Potential Treatment of Rare Disease Lymphangioleiomyomatosis
by: Stella Bähr, et al.
Published: (2024-09-01)

Optimizing Blood Pressure Control: A Randomized Comparative Trial of Losartan/Chlorthalidone vs. Losartan/Hydrochlorothiazide
by: Isabel E. Rucker-Joerg, et al.
Published: (2025-04-01)

A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics
by: Richard Head, et al.
Published: (2025-08-01)

Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation
by: Chawalit Ngernsombat, et al.
Published: (2024-12-01)

Comparative analysis of phytocompounds and repurposed drugs against dengue virus serotypes employing an in silico study
by: Pranjal Vats, et al.
Published: (2025-07-01)

Bioadhesive Eudragit RL<sup>®</sup>100 Nanocapsules for Melanoma Therapy: A Repurposing Strategy for Propranolol
by: Naomi Gerzvolf Mieres, et al.
Published: (2025-05-01)

Repurposing drugs: Lessons from rheumatology in the COVID-19 pandemic
by: Manesh Manoj, et al.
Published: (2021-01-01)

IUPHAR review: Drug repurposing in Schizophrenia – An updated review of clinical trials
by: Jihan K. Zaki, et al.
Published: (2025-03-01)

Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms
by: She Pengfei, et al.
Published: (2024-12-01)

Utilization of Localized Surface Plasmon Resonance of Silver Nanoparticles for ‎the Spectrophotometric Estimation of Amlodipine and Hydrochlorothiazide
by: Rasul Jameel Ali, et al.
Published: (2024-11-01)

Simultaneous Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC-MS/MS
by: P. K. Karnakova, et al.
Published: (2021-11-01)

Spectrophotometric Determination of Losartan Potassium and Hydrochlorothiazide in tablets by Wavelet Transform Approach
by: Özgür Üstündağ, et al.
Published: (2021-12-01)

Drug repurposing of fostamatinib against cancer via potential cytotoxicity and immune checkpoint regulation
by: Maoqiong Hu, et al.
Published: (2025-05-01)

Repurposed Antipsychotics as Potential Anticancer Agents: Clozapine Efficacy and Dopaminergic Pathways in Neuroblastoma and Glioblastoma
by: Catarina Moura, et al.
Published: (2025-07-01)