Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats
Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved. Two doses (10 and 100 mg/kg) of CoQ10 were administered ora...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2012/981461 |
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| author | Azza A. K. El-Sheikh Mohamed A. Morsy Marwa M. Mahmoud Rehab A. Rifaai Aly M. Abdelrahman |
| author_facet | Azza A. K. El-Sheikh Mohamed A. Morsy Marwa M. Mahmoud Rehab A. Rifaai Aly M. Abdelrahman |
| author_sort | Azza A. K. El-Sheikh |
| collection | DOAJ |
| description | Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved. Two doses (10 and 100 mg/kg) of CoQ10 were administered orally to rats for 8 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of Dox (15 mg/kg) at day 4 of the experiment. Our results showed that the low dose of CoQ10 succeeded in reversing Dox-induced nephrotoxicity to control levels (e.g., levels of blood urea nitrogen and serum creatinine, concentrations of renal reduced glutathione (GSH) and malondialdehyde, catalase activity and caspase 3 expression, and renal histopathology). Alternatively, the high dose of CoQ10 showed no superior nephroprotection over the low dose, as there were no significant improvements in renal histopathology, catalase activity, or caspase 3 expression compared to the Dox-treated group. Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10. We conclude that CoQ10 protects from Dox-induced nephrotoxicity with a precaution to dosage adjustment. |
| format | Article |
| id | doaj-art-1684f7c50a2d4287a71f8382ed12e9fc |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-1684f7c50a2d4287a71f8382ed12e9fc2025-02-03T01:32:56ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422012-01-01201210.1155/2012/981461981461Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in RatsAzza A. K. El-Sheikh0Mohamed A. Morsy1Marwa M. Mahmoud2Rehab A. Rifaai3Aly M. Abdelrahman4Department of Pharmacology, Faculty of Medicine, Minia University, 61511 El-Minia, EgyptDepartment of Pharmacology, Faculty of Medicine, Minia University, 61511 El-Minia, EgyptDepartment of Pharmacology, Faculty of Medicine, Minia University, 61511 El-Minia, EgyptDepartment of Histology, Faculty of Medicine, Minia University, 61511 El-Minia, EgyptDepartment of Pharmacology, Faculty of Medicine, Minia University, 61511 El-Minia, EgyptNephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and the mechanisms involved. Two doses (10 and 100 mg/kg) of CoQ10 were administered orally to rats for 8 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of Dox (15 mg/kg) at day 4 of the experiment. Our results showed that the low dose of CoQ10 succeeded in reversing Dox-induced nephrotoxicity to control levels (e.g., levels of blood urea nitrogen and serum creatinine, concentrations of renal reduced glutathione (GSH) and malondialdehyde, catalase activity and caspase 3 expression, and renal histopathology). Alternatively, the high dose of CoQ10 showed no superior nephroprotection over the low dose, as there were no significant improvements in renal histopathology, catalase activity, or caspase 3 expression compared to the Dox-treated group. Interestingly, the high dose of CoQ10 alone significantly decreased renal GSH level as well as catalase activity and caused a mild induction of caspase 3 expression compared to control, probably due to a prooxidant effect at this dose of CoQ10. We conclude that CoQ10 protects from Dox-induced nephrotoxicity with a precaution to dosage adjustment.http://dx.doi.org/10.1155/2012/981461 |
| spellingShingle | Azza A. K. El-Sheikh Mohamed A. Morsy Marwa M. Mahmoud Rehab A. Rifaai Aly M. Abdelrahman Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats Advances in Pharmacological Sciences |
| title | Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats |
| title_full | Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats |
| title_fullStr | Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats |
| title_full_unstemmed | Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats |
| title_short | Effect of Coenzyme-Q10 on Doxorubicin-Induced Nephrotoxicity in Rats |
| title_sort | effect of coenzyme q10 on doxorubicin induced nephrotoxicity in rats |
| url | http://dx.doi.org/10.1155/2012/981461 |
| work_keys_str_mv | AT azzaakelsheikh effectofcoenzymeq10ondoxorubicininducednephrotoxicityinrats AT mohamedamorsy effectofcoenzymeq10ondoxorubicininducednephrotoxicityinrats AT marwammahmoud effectofcoenzymeq10ondoxorubicininducednephrotoxicityinrats AT rehabarifaai effectofcoenzymeq10ondoxorubicininducednephrotoxicityinrats AT alymabdelrahman effectofcoenzymeq10ondoxorubicininducednephrotoxicityinrats |