The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats
Aim. The aim of this study was to compare the effects of sildenafil and trimetazidine on bilateral cavernosal nerve injury-induced oxidative damage and fibrotic changes in cavernosal tissue in rat model. Material and Methods. A total of 32 male Sprague-Dawley rats were randomly divided into 4 groups...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/970363 |
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| author | Dogan Atilgan Bekir S. Parlaktas Nihat Uluocak Fikret Erdemir Fatma Markoc Oguzhan Saylan Unal Erkorkmaz |
| author_facet | Dogan Atilgan Bekir S. Parlaktas Nihat Uluocak Fikret Erdemir Fatma Markoc Oguzhan Saylan Unal Erkorkmaz |
| author_sort | Dogan Atilgan |
| collection | DOAJ |
| description | Aim. The aim of this study was to compare the effects of sildenafil and trimetazidine on bilateral cavernosal nerve injury-induced oxidative damage and fibrotic changes in cavernosal tissue in rat model. Material and Methods. A total of 32 male Sprague-Dawley rats were randomly divided into 4 groups; each group consist 8 rats (control, BCI, BCI + TMZ, and BCI + sildenafil groups). Tissue superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) levels were determined biochemically and distribution of cavernosal fibrosis density among groups was performed histopathologically. Results. Tissue SOD levels in BCI group were significantly lower than the control group (P<0.05). Tissue MDA and PC levels in BCI group were significantly higher than the control group (P<0.05). TMZ and sildenafil administration significantly increased tissue SOD levels (P<0.05) and reduced tissue MDA and PC levels (P<0.05). Histologically, the degree of cavernosal fibrosis and collagen density was higher in BCI group in comparison to control, TMZ-treated, and sildenafil-treated groups. Conclusion. BCI caused oxidative damage and increased cavernosal fibrosis in rat penis. TMZ and sildenafil treatment decreased oxidative damage and reduced the degree of fibrosis in penile tissue due to BCI. |
| format | Article |
| id | doaj-art-1682edec765a47a090a581c3e64436de |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1682edec765a47a090a581c3e64436de2025-02-03T01:25:37ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/970363970363The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in RatsDogan Atilgan0Bekir S. Parlaktas1Nihat Uluocak2Fikret Erdemir3Fatma Markoc4Oguzhan Saylan5Unal Erkorkmaz6Department of Urology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyDepartment of Urology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyDepartment of Urology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyDepartment of Urology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyDepartment of Pathology, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyDepartment of Biochemistry, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyDepartment of Biostatistics, Medical Faculty, Gaziosmanpasa University, 60100 Tokat, TurkeyAim. The aim of this study was to compare the effects of sildenafil and trimetazidine on bilateral cavernosal nerve injury-induced oxidative damage and fibrotic changes in cavernosal tissue in rat model. Material and Methods. A total of 32 male Sprague-Dawley rats were randomly divided into 4 groups; each group consist 8 rats (control, BCI, BCI + TMZ, and BCI + sildenafil groups). Tissue superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) levels were determined biochemically and distribution of cavernosal fibrosis density among groups was performed histopathologically. Results. Tissue SOD levels in BCI group were significantly lower than the control group (P<0.05). Tissue MDA and PC levels in BCI group were significantly higher than the control group (P<0.05). TMZ and sildenafil administration significantly increased tissue SOD levels (P<0.05) and reduced tissue MDA and PC levels (P<0.05). Histologically, the degree of cavernosal fibrosis and collagen density was higher in BCI group in comparison to control, TMZ-treated, and sildenafil-treated groups. Conclusion. BCI caused oxidative damage and increased cavernosal fibrosis in rat penis. TMZ and sildenafil treatment decreased oxidative damage and reduced the degree of fibrosis in penile tissue due to BCI.http://dx.doi.org/10.1155/2014/970363 |
| spellingShingle | Dogan Atilgan Bekir S. Parlaktas Nihat Uluocak Fikret Erdemir Fatma Markoc Oguzhan Saylan Unal Erkorkmaz The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats The Scientific World Journal |
| title | The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats |
| title_full | The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats |
| title_fullStr | The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats |
| title_full_unstemmed | The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats |
| title_short | The Effects of Trimetazidine and Sildenafil on Bilateral Cavernosal Nerve Injury Induced Oxidative Damage and Cavernosal Fibrosis in Rats |
| title_sort | effects of trimetazidine and sildenafil on bilateral cavernosal nerve injury induced oxidative damage and cavernosal fibrosis in rats |
| url | http://dx.doi.org/10.1155/2014/970363 |
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