Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis
<b>Introduction</b>: Knee osteoarthritis (OA) is defined by articular cartilage loss, increased discomfort, and functional restrictions. Changes in lifestyle, painkillers, intra-articular injections, and, as a last resort, surgery are all part of clinical therapy. In this setting, intra-...
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2025-07-01
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| author | Vincenzo Rania Cristina Vocca Gianmarco Marcianò Maria Cristina Caroleo Lucia Muraca Emanuele Toraldo Francesca Greco Caterina Palleria Gian Pietro Emerenziani Luca Gallelli |
| author_facet | Vincenzo Rania Cristina Vocca Gianmarco Marcianò Maria Cristina Caroleo Lucia Muraca Emanuele Toraldo Francesca Greco Caterina Palleria Gian Pietro Emerenziani Luca Gallelli |
| author_sort | Vincenzo Rania |
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| description | <b>Introduction</b>: Knee osteoarthritis (OA) is defined by articular cartilage loss, increased discomfort, and functional restrictions. Changes in lifestyle, painkillers, intra-articular injections, and, as a last resort, surgery are all part of clinical therapy. In this setting, intra-articular injections of hyaluronic acid (HA) represent a relevant and diffused therapeutic option. <b>Materials and Methods</b>: A prospective observational study was performed from October 2024 to May 2025 in 70 patients with knee OA. HA was administered in three intra-articular injections and was followed up at 3 and 6 months from the last injection. Knee Injury and Osteoarthritis Outcome Score (KOOS) was evaluated as primary outcome measure; Visual Analogue Scale (VAS), time up and go test, six-minute walking test, general health assessment with 36-Item Short Form Health Survey (SF-36), Zung’s Self-Rating Anxiety Scale (Zung SAS), and Zung’s Self-Rating Depression Scale (Zung SDS) as secondary outcome measures. <b>Results</b>: We observed a statistically significant improvement in clinical scores at 3 months in both HA formulations compared to the control group. No relevant side effects were described during the study. <b>Conclusion</b>: Hyalubrix 30 mg/2 mL and DIART 1.8%/2 mL are two safe and effective therapeutic options to manage knee OA, offering benefits in pain control, functionality and emotional wellness. |
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| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-167fa214830f4eeea36b085018fb0f7f2025-08-20T03:32:17ZengMDPI AGPharmaceuticals1424-82472025-07-01187106510.3390/ph18071065Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee OsteoarthritisVincenzo Rania0Cristina Vocca1Gianmarco Marcianò2Maria Cristina Caroleo3Lucia Muraca4Emanuele Toraldo5Francesca Greco6Caterina Palleria7Gian Pietro Emerenziani8Luca Gallelli9Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco” University Hospital, 88100 Catanzaro, ItalyDepartment of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyResearch Center FAS@UMG, Department of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, Catanzaro University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, Catanzaro University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco” University Hospital, 88100 Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, Catanzaro University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco” University Hospital, 88100 Catanzaro, Italy<b>Introduction</b>: Knee osteoarthritis (OA) is defined by articular cartilage loss, increased discomfort, and functional restrictions. Changes in lifestyle, painkillers, intra-articular injections, and, as a last resort, surgery are all part of clinical therapy. In this setting, intra-articular injections of hyaluronic acid (HA) represent a relevant and diffused therapeutic option. <b>Materials and Methods</b>: A prospective observational study was performed from October 2024 to May 2025 in 70 patients with knee OA. HA was administered in three intra-articular injections and was followed up at 3 and 6 months from the last injection. Knee Injury and Osteoarthritis Outcome Score (KOOS) was evaluated as primary outcome measure; Visual Analogue Scale (VAS), time up and go test, six-minute walking test, general health assessment with 36-Item Short Form Health Survey (SF-36), Zung’s Self-Rating Anxiety Scale (Zung SAS), and Zung’s Self-Rating Depression Scale (Zung SDS) as secondary outcome measures. <b>Results</b>: We observed a statistically significant improvement in clinical scores at 3 months in both HA formulations compared to the control group. No relevant side effects were described during the study. <b>Conclusion</b>: Hyalubrix 30 mg/2 mL and DIART 1.8%/2 mL are two safe and effective therapeutic options to manage knee OA, offering benefits in pain control, functionality and emotional wellness.https://www.mdpi.com/1424-8247/18/7/1065hyaluronic acidtriple injectionlinearknee osteoarthritissafetyefficacy |
| spellingShingle | Vincenzo Rania Cristina Vocca Gianmarco Marcianò Maria Cristina Caroleo Lucia Muraca Emanuele Toraldo Francesca Greco Caterina Palleria Gian Pietro Emerenziani Luca Gallelli Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis Pharmaceuticals hyaluronic acid triple injection linear knee osteoarthritis safety efficacy |
| title | Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis |
| title_full | Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis |
| title_fullStr | Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis |
| title_full_unstemmed | Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis |
| title_short | Comparative Efficacy and Safety of Two Different Formulations of Linear Hyaluronic Acid in Patients with Knee Osteoarthritis |
| title_sort | comparative efficacy and safety of two different formulations of linear hyaluronic acid in patients with knee osteoarthritis |
| topic | hyaluronic acid triple injection linear knee osteoarthritis safety efficacy |
| url | https://www.mdpi.com/1424-8247/18/7/1065 |
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