Prevalence of thyroid dysfunction in metabolic syndrome
Background: Metabolic syndrome is a pathologic state characterized by abdominal obesity, hypertension, insulin resistance, and hyperlipidemia. Thyroid hormones significantly affect lipid metabolism and dysfunction of the same can potentially increase the risk of coronary heart disease. Aim and Objec...
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| Language: | English |
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Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2024-10-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
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| Online Access: | https://www.jkimsu.com/jkimsu-vol13no4/JKIMSU,%20Vol.%2013,%20No.%204,%20October-December%202024%20Page%2095-105.pdf |
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| author | Saajid Anwar Yoganathan Chidambaram Clement Jenil Dhas C P Sujith Kumar |
| author_facet | Saajid Anwar Yoganathan Chidambaram Clement Jenil Dhas C P Sujith Kumar |
| author_sort | Saajid Anwar |
| collection | DOAJ |
| description | Background: Metabolic syndrome is a pathologic state characterized by abdominal obesity, hypertension, insulin resistance, and hyperlipidemia. Thyroid hormones significantly affect lipid metabolism and dysfunction of the same can potentially increase the risk of coronary heart disease. Aim and Objectives: To assess the changes in thyroid parameters in patients suffering from metabolic syndrome. Material and Methods: The present study was a cross-sectional study conducted at a tertiary healthcare centre and included subjects aged more than 18 years with a waist circumference > 90 cm for men and > 80 cm for women along with any two of the criteria: Triglycerides > 150 mg/dL, HDL< 40 mg/dL (men), < 50 mg/dL (women), Systolic Blood Pressure (SBP) > 130 mmHg, Diastolic Blood Pressure (DBP) > 85 mm Hg, Fasting Blood Glucose (FBS) > 100 mg/dL. Blood samples were taken from patients for glucose, lipid profile, and thyroid function tests and correlation was obtained. Results: Among the 141 patients enrolled in the study, 59.6% individuals had TSH in the euthyroid range, 39.7% in hypothyroid range, and 0.7% in the hyperthyroid range. Additionally, 75% individuals had free T4 in the euthyroid range, 6% in the hyperthyroid range and 19% in the hypothyroid range. Of the participants in the hypothyroid range, 45.7% were overweight, 33.3% were obese, and 25% were severely obese. There was only one hyperthyroid participant who was overweight. However, none of the assessed parameters showed a statistically significant association with TSH levels among the participants. Conclusion: The results show that there is no direct association between thyroid dysfunction and individual parameters of metabolic syndrome, However, subclinical hypothyroidism is prevalent among metabolic syndrome patients hence making evaluation for thyroid disease in these patients a priority. |
| format | Article |
| id | doaj-art-167f8564d59e4c5a95a6a66ce2099a57 |
| institution | Kabale University |
| issn | 2231-4261 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj-art-167f8564d59e4c5a95a6a66ce2099a572025-08-20T03:42:25ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612024-10-0113495105Prevalence of thyroid dysfunction in metabolic syndromeSaajid Anwar0Yoganathan Chidambaram1Clement Jenil Dhas C P2Sujith Kumar3Sri Ramachandra Institute of Higher Education and Research, Porur Chennai-600116 (Tamil Nadu) IndiaDepartment of General Medicine, PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore-641004 (Tamil Nadu) IndiaDepartment of General Medicine, PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore-641004 (Tamil Nadu) IndiaDepartment of General Medicine, PSG Institute of Medical Sciences & Research, Peelamedu, Coimbatore-641004 (Tamil Nadu) IndiaBackground: Metabolic syndrome is a pathologic state characterized by abdominal obesity, hypertension, insulin resistance, and hyperlipidemia. Thyroid hormones significantly affect lipid metabolism and dysfunction of the same can potentially increase the risk of coronary heart disease. Aim and Objectives: To assess the changes in thyroid parameters in patients suffering from metabolic syndrome. Material and Methods: The present study was a cross-sectional study conducted at a tertiary healthcare centre and included subjects aged more than 18 years with a waist circumference > 90 cm for men and > 80 cm for women along with any two of the criteria: Triglycerides > 150 mg/dL, HDL< 40 mg/dL (men), < 50 mg/dL (women), Systolic Blood Pressure (SBP) > 130 mmHg, Diastolic Blood Pressure (DBP) > 85 mm Hg, Fasting Blood Glucose (FBS) > 100 mg/dL. Blood samples were taken from patients for glucose, lipid profile, and thyroid function tests and correlation was obtained. Results: Among the 141 patients enrolled in the study, 59.6% individuals had TSH in the euthyroid range, 39.7% in hypothyroid range, and 0.7% in the hyperthyroid range. Additionally, 75% individuals had free T4 in the euthyroid range, 6% in the hyperthyroid range and 19% in the hypothyroid range. Of the participants in the hypothyroid range, 45.7% were overweight, 33.3% were obese, and 25% were severely obese. There was only one hyperthyroid participant who was overweight. However, none of the assessed parameters showed a statistically significant association with TSH levels among the participants. Conclusion: The results show that there is no direct association between thyroid dysfunction and individual parameters of metabolic syndrome, However, subclinical hypothyroidism is prevalent among metabolic syndrome patients hence making evaluation for thyroid disease in these patients a priority.https://www.jkimsu.com/jkimsu-vol13no4/JKIMSU,%20Vol.%2013,%20No.%204,%20October-December%202024%20Page%2095-105.pdfmetabolic syndromethyroid diseasetriglyceridehyperthyroid |
| spellingShingle | Saajid Anwar Yoganathan Chidambaram Clement Jenil Dhas C P Sujith Kumar Prevalence of thyroid dysfunction in metabolic syndrome Journal of Krishna Institute of Medical Sciences University metabolic syndrome thyroid disease triglyceride hyperthyroid |
| title | Prevalence of thyroid dysfunction in metabolic syndrome |
| title_full | Prevalence of thyroid dysfunction in metabolic syndrome |
| title_fullStr | Prevalence of thyroid dysfunction in metabolic syndrome |
| title_full_unstemmed | Prevalence of thyroid dysfunction in metabolic syndrome |
| title_short | Prevalence of thyroid dysfunction in metabolic syndrome |
| title_sort | prevalence of thyroid dysfunction in metabolic syndrome |
| topic | metabolic syndrome thyroid disease triglyceride hyperthyroid |
| url | https://www.jkimsu.com/jkimsu-vol13no4/JKIMSU,%20Vol.%2013,%20No.%204,%20October-December%202024%20Page%2095-105.pdf |
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