Brain microdialysis in neurobiology and neurochemistry

Microdialysis is a versatile and popular minimally invasive technique which enables sampling, collecting, and continuous measurement of small-molecular-weight substances in the extracellular fluid of virtually any tissue. Widely established in pharmacology and neuroscience, it permits evaluation of...

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Main Authors: E. V. Kharitonova, O. L. Lopatina, S. A. Marchenko, Y. V. Gorina, A. B. Salmina
Format: Article
Language:Russian
Published: Kemerovo State Medical University 2020-09-01
Series:Фундаментальная и клиническая медицина
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Online Access:https://fcm.kemsmu.ru/jour/article/view/302
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author E. V. Kharitonova
O. L. Lopatina
S. A. Marchenko
Y. V. Gorina
A. B. Salmina
author_facet E. V. Kharitonova
O. L. Lopatina
S. A. Marchenko
Y. V. Gorina
A. B. Salmina
author_sort E. V. Kharitonova
collection DOAJ
description Microdialysis is a versatile and popular minimally invasive technique which enables sampling, collecting, and continuous measurement of small-molecular-weight substances in the extracellular fluid of virtually any tissue. Widely established in pharmacology and neuroscience, it permits evaluation of the metabolism in any organ including brain and allows early detection of the cell stress. Concentrations of the target analytes in the dialysate are determined by the type of the analysed tissue, paracrine interactions, and technical features such as membrane type and surface area or flow rate of isotonic fluid. Cerebral (or brain) microdialysis can be used in personalised pharmacotherapy and prognostication in patients with neurological disorders. Here we discuss recent advances in brain microdialysis and focus on critical parameters defining its efficiency.
format Article
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institution Kabale University
issn 2500-0764
2542-0941
language Russian
publishDate 2020-09-01
publisher Kemerovo State Medical University
record_format Article
series Фундаментальная и клиническая медицина
spelling doaj-art-167ece45ad054783963c94272dfceda82025-08-20T03:42:38ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412020-09-0153859710.23946/2500-0764-2020-5-3-85-97221Brain microdialysis in neurobiology and neurochemistryE. V. Kharitonova0O. L. Lopatina1S. A. Marchenko2Y. V. Gorina3A. B. Salmina4Voino-Yasenetskiy Krasnoyarsk State Medical UniversityVoino-Yasenetskiy Krasnoyarsk State Medical University; Siberian Federal UniversityVoino-Yasenetskiy Krasnoyarsk State Medical UniversityVoino-Yasenetskiy Krasnoyarsk State Medical UniversityVoino-Yasenetskiy Krasnoyarsk State Medical UniversityMicrodialysis is a versatile and popular minimally invasive technique which enables sampling, collecting, and continuous measurement of small-molecular-weight substances in the extracellular fluid of virtually any tissue. Widely established in pharmacology and neuroscience, it permits evaluation of the metabolism in any organ including brain and allows early detection of the cell stress. Concentrations of the target analytes in the dialysate are determined by the type of the analysed tissue, paracrine interactions, and technical features such as membrane type and surface area or flow rate of isotonic fluid. Cerebral (or brain) microdialysis can be used in personalised pharmacotherapy and prognostication in patients with neurological disorders. Here we discuss recent advances in brain microdialysis and focus on critical parameters defining its efficiency.https://fcm.kemsmu.ru/jour/article/view/302brain microdialysisneuroscienceneurodegenerative diseasesneurobiologyneurochemistry
spellingShingle E. V. Kharitonova
O. L. Lopatina
S. A. Marchenko
Y. V. Gorina
A. B. Salmina
Brain microdialysis in neurobiology and neurochemistry
Фундаментальная и клиническая медицина
brain microdialysis
neuroscience
neurodegenerative diseases
neurobiology
neurochemistry
title Brain microdialysis in neurobiology and neurochemistry
title_full Brain microdialysis in neurobiology and neurochemistry
title_fullStr Brain microdialysis in neurobiology and neurochemistry
title_full_unstemmed Brain microdialysis in neurobiology and neurochemistry
title_short Brain microdialysis in neurobiology and neurochemistry
title_sort brain microdialysis in neurobiology and neurochemistry
topic brain microdialysis
neuroscience
neurodegenerative diseases
neurobiology
neurochemistry
url https://fcm.kemsmu.ru/jour/article/view/302
work_keys_str_mv AT evkharitonova brainmicrodialysisinneurobiologyandneurochemistry
AT ollopatina brainmicrodialysisinneurobiologyandneurochemistry
AT samarchenko brainmicrodialysisinneurobiologyandneurochemistry
AT yvgorina brainmicrodialysisinneurobiologyandneurochemistry
AT absalmina brainmicrodialysisinneurobiologyandneurochemistry