Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy
Abstract Photothermal therapy (PTT), a vanguard strategy in cancer/ocular neovascularization treatment, has attracted considerable attention owing to its precision, controllability, high efficacy, and minimal side effects. Nevertheless, its inherent limitations necessitate innovative solutions. One...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-60454-5 |
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| author | Mei Yang Yida Huang Zhongxing Chen Qianfang Ye Zhenhai Zeng Xinru You Bijun Bao Wenqian Xing Nan Zhao Zhilin Zou Hongxian Pan Xin Chen Qingyi Gao Tingting Chen Shenrong Zhang Aodong Chen Yichen Xiao Huilin Xu Jiawei Li Yongjiang Li Na Kong Wei Tao Xingtao Zhou Jinhai Huang |
| author_facet | Mei Yang Yida Huang Zhongxing Chen Qianfang Ye Zhenhai Zeng Xinru You Bijun Bao Wenqian Xing Nan Zhao Zhilin Zou Hongxian Pan Xin Chen Qingyi Gao Tingting Chen Shenrong Zhang Aodong Chen Yichen Xiao Huilin Xu Jiawei Li Yongjiang Li Na Kong Wei Tao Xingtao Zhou Jinhai Huang |
| author_sort | Mei Yang |
| collection | DOAJ |
| description | Abstract Photothermal therapy (PTT), a vanguard strategy in cancer/ocular neovascularization treatment, has attracted considerable attention owing to its precision, controllability, high efficacy, and minimal side effects. Nevertheless, its inherent limitations necessitate innovative solutions. One promising strategy is to develop reagents with enhanced photothermal conversion efficiency under long-wavelength laser irradiation. Carbon nanomaterials, known for their broad absorption spectra, are currently hindered by single-wavelength lasers in clinical treatments. In this study, we address this limitation by coating mesoporous carbon nanomaterials (MCNs) with a lanthanide oxysulfide up-conversion material (Y2O2S:Yb3+,Er3+), converting 980 nm light into visible light. This advancement enhances the photothermal conversion efficiency of the produced MCNs/Ln/GD/FR nanocomposites from 59.48% to 82.86%. Furthermore, the incorporation of gambogic acid and doxorubicin intensifies the synergistic photothermal therapy effect. A dual stimuli-responsive hydrogel (PNIPAM) is employed to ensure controlled drug release and safe delivery to tumors. Evaluations demonstrate that the MCNs/Ln/GD/FR nanocomposites exhibit exceptional tumor targeting and evident photothermal synergistic therapy effects on both subcutaneous and ocular in situ melanoma tumors by activating tumor-suppressive signaling pathways while inhibiting proliferation and differentiation-related pathways. These findings might pave the way for the development of photothermal reagent and offer valuable insights for advancing therapeutic strategies. |
| format | Article |
| id | doaj-art-167e6e36087f47689f841fbd6c5fa671 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-167e6e36087f47689f841fbd6c5fa6712025-08-20T03:46:12ZengNature PortfolioNature Communications2041-17232025-07-0116112110.1038/s41467-025-60454-5Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapyMei Yang0Yida Huang1Zhongxing Chen2Qianfang Ye3Zhenhai Zeng4Xinru You5Bijun Bao6Wenqian Xing7Nan Zhao8Zhilin Zou9Hongxian Pan10Xin Chen11Qingyi Gao12Tingting Chen13Shenrong Zhang14Aodong Chen15Yichen Xiao16Huilin Xu17Jiawei Li18Yongjiang Li19Na Kong20Wei Tao21Xingtao Zhou22Jinhai Huang23Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical SchoolSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesSchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversitySchool of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical SchoolCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical SchoolCenter for Nanomedicine and Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical SchoolEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesEye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University; NHC Key Laboratory of Myopia and Related Eye DiseasesAbstract Photothermal therapy (PTT), a vanguard strategy in cancer/ocular neovascularization treatment, has attracted considerable attention owing to its precision, controllability, high efficacy, and minimal side effects. Nevertheless, its inherent limitations necessitate innovative solutions. One promising strategy is to develop reagents with enhanced photothermal conversion efficiency under long-wavelength laser irradiation. Carbon nanomaterials, known for their broad absorption spectra, are currently hindered by single-wavelength lasers in clinical treatments. In this study, we address this limitation by coating mesoporous carbon nanomaterials (MCNs) with a lanthanide oxysulfide up-conversion material (Y2O2S:Yb3+,Er3+), converting 980 nm light into visible light. This advancement enhances the photothermal conversion efficiency of the produced MCNs/Ln/GD/FR nanocomposites from 59.48% to 82.86%. Furthermore, the incorporation of gambogic acid and doxorubicin intensifies the synergistic photothermal therapy effect. A dual stimuli-responsive hydrogel (PNIPAM) is employed to ensure controlled drug release and safe delivery to tumors. Evaluations demonstrate that the MCNs/Ln/GD/FR nanocomposites exhibit exceptional tumor targeting and evident photothermal synergistic therapy effects on both subcutaneous and ocular in situ melanoma tumors by activating tumor-suppressive signaling pathways while inhibiting proliferation and differentiation-related pathways. These findings might pave the way for the development of photothermal reagent and offer valuable insights for advancing therapeutic strategies.https://doi.org/10.1038/s41467-025-60454-5 |
| spellingShingle | Mei Yang Yida Huang Zhongxing Chen Qianfang Ye Zhenhai Zeng Xinru You Bijun Bao Wenqian Xing Nan Zhao Zhilin Zou Hongxian Pan Xin Chen Qingyi Gao Tingting Chen Shenrong Zhang Aodong Chen Yichen Xiao Huilin Xu Jiawei Li Yongjiang Li Na Kong Wei Tao Xingtao Zhou Jinhai Huang Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy Nature Communications |
| title | Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy |
| title_full | Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy |
| title_fullStr | Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy |
| title_full_unstemmed | Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy |
| title_short | Synthetic carbon-based lanthanide upconversion nanoparticles for enhanced photothermal therapy |
| title_sort | synthetic carbon based lanthanide upconversion nanoparticles for enhanced photothermal therapy |
| url | https://doi.org/10.1038/s41467-025-60454-5 |
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