Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model
Background: Despite the control of Bordetella pertussis with vaccine introduction, the incidence of pertussis has increased in the United States and globally. New vaccine strategies are clearly needed to regain control of this vaccine-preventable infection. Methods: Experimental pertussis infect...
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| Format: | Article |
| Language: | English |
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Case Western Reserve University
2025-06-01
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| Series: | Pathogens and Immunity |
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| Online Access: | https://www.paijournal.com/index.php/paijournal/article/view/800 |
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| author | Gaurav Chauhan Melissa Gawron Aaron Belli Keith Reimann Ryan Schneider Yang Wang Mark Klempner Lisa Cavacini |
| author_facet | Gaurav Chauhan Melissa Gawron Aaron Belli Keith Reimann Ryan Schneider Yang Wang Mark Klempner Lisa Cavacini |
| author_sort | Gaurav Chauhan |
| collection | DOAJ |
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Background: Despite the control of Bordetella pertussis with vaccine introduction, the incidence of pertussis has increased in the United States and globally. New vaccine strategies are clearly needed to regain control of this vaccine-preventable infection.
Methods: Experimental pertussis infection of baboons induces an acute respiratory illness with clinical and laboratory features similar to whooping cough in man. In a previous study, acellular pertussis-vaccinated (aP) baboons were protected from clinical illness but not from prolonged airway colonization. In contrast, convalescent baboons are protected from both clinical illness and colonization. These studies suggest that current aP vaccines may be ineffective at preventing airway colonization, contributing to resurgence of pertussis.
Results: In studies conducted at the University of Massachusetts Chan Medical School in Worcester, Massachusetts, mucosal IgG antibody responses in nasopharyngeal washes are similar in convalescent and vaccinated baboons. However, significantly higher mucosal anti-pertussis immunoglobulin A (IgA) responses are observed in convalescent animals.
Conclusions: These studies suggest that mucosal IgA responses to some pertussis antigens will result in bacterial clearance.
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| format | Article |
| id | doaj-art-167cd9cbf4f54fff83bdd70e612f2c96 |
| institution | Kabale University |
| issn | 2469-2964 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Case Western Reserve University |
| record_format | Article |
| series | Pathogens and Immunity |
| spelling | doaj-art-167cd9cbf4f54fff83bdd70e612f2c962025-08-20T03:25:59ZengCase Western Reserve UniversityPathogens and Immunity2469-29642025-06-0110210.20411/pai.v10i2.800Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon ModelGaurav Chauhan0Melissa Gawron1Aaron Belli2Keith Reimann3Ryan Schneider4Yang Wang5Mark Klempner6Lisa Cavacini7https://orcid.org/0000-0003-1417-8339Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MassachusettsDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts Background: Despite the control of Bordetella pertussis with vaccine introduction, the incidence of pertussis has increased in the United States and globally. New vaccine strategies are clearly needed to regain control of this vaccine-preventable infection. Methods: Experimental pertussis infection of baboons induces an acute respiratory illness with clinical and laboratory features similar to whooping cough in man. In a previous study, acellular pertussis-vaccinated (aP) baboons were protected from clinical illness but not from prolonged airway colonization. In contrast, convalescent baboons are protected from both clinical illness and colonization. These studies suggest that current aP vaccines may be ineffective at preventing airway colonization, contributing to resurgence of pertussis. Results: In studies conducted at the University of Massachusetts Chan Medical School in Worcester, Massachusetts, mucosal IgG antibody responses in nasopharyngeal washes are similar in convalescent and vaccinated baboons. However, significantly higher mucosal anti-pertussis immunoglobulin A (IgA) responses are observed in convalescent animals. Conclusions: These studies suggest that mucosal IgA responses to some pertussis antigens will result in bacterial clearance. https://www.paijournal.com/index.php/paijournal/article/view/800Bordetella pertussisWhooping CoughMucosal IgA |
| spellingShingle | Gaurav Chauhan Melissa Gawron Aaron Belli Keith Reimann Ryan Schneider Yang Wang Mark Klempner Lisa Cavacini Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model Pathogens and Immunity Bordetella pertussis Whooping Cough Mucosal IgA |
| title | Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model |
| title_full | Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model |
| title_fullStr | Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model |
| title_full_unstemmed | Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model |
| title_short | Mucosal IgA Antibodies are Critical for Bacterial Clearance of Bordetella pertussis in the Baboon Model |
| title_sort | mucosal iga antibodies are critical for bacterial clearance of bordetella pertussis in the baboon model |
| topic | Bordetella pertussis Whooping Cough Mucosal IgA |
| url | https://www.paijournal.com/index.php/paijournal/article/view/800 |
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