Single-molecule imaging prefusion intermediate conformations of MERS-CoV spike trimers in membrane during entry

Single-molecule imaging prefusion intermediate conformations of MERS-CoV spike trimers in membrane during entry

Summary: Middle East respiratory syndrome coronavirus (MERS-CoV) entry into host cells is mediated by the spike (S) glycoprotein trimer. The S2 domain of spike promotes membrane fusion for MERS entry, but its mechanism of action is currently elusive. Here, we applied real-time single-molecule fluore...

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Bibliographic Details
Main Authors: Shuvankar Dey, Purba Pahari, Mridul Shukla, Raiees Andrabi, Dibyendu Kumar Das
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006874
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