Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT)
Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of chronic kidney disease in children. Most patients will reach end-stage renal function and dialysis or transplantation in childhood or early adulthood. Patients with CAKUT deserve a careful evaluation before a kidney t...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/4/932 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849712420067475456 |
|---|---|
| author | Silvio Maringhini Lars Pape |
| author_facet | Silvio Maringhini Lars Pape |
| author_sort | Silvio Maringhini |
| collection | DOAJ |
| description | Congenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of chronic kidney disease in children. Most patients will reach end-stage renal function and dialysis or transplantation in childhood or early adulthood. Patients with CAKUT deserve a careful evaluation before a kidney transplant; detailed imaging and functional studies are necessary, particularly in the presence of lower urinary tract abnormalities, and surgical procedures are advisable in selected cases. A higher incidence of complications has been reported after a kidney transplant in CAKUT, mainly urinary tract infections. However, in the long term, the prognosis seems to be comparable to other kidney diseases. A large number of reports are available in the literature on medical and surgical management of patients with CAKUT before, during, and after a kidney transplant; almost all recommendations of surgical procedures before a kidney transplantation are based on retrospective not controlled studies or personal opinions; prospective controlled studies are needed. In this narrative, nonsystematic review, we report the results of recently published selected studies and underline questions that should be addressed in future guidelines. |
| format | Article |
| id | doaj-art-1675eb99b1394dc8a7e1014239ead950 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-1675eb99b1394dc8a7e1014239ead9502025-08-20T03:14:16ZengMDPI AGBiomedicines2227-90592025-04-0113493210.3390/biomedicines13040932Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT)Silvio Maringhini0Lars Pape1Department of Pediatrics, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Via Ernesto Tricomi, 5, 90127 Palermo, ItalyDepartment of Pediatrics II, University Hospital of Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147 Essen, GermanyCongenital anomalies of the kidney and urinary tract (CAKUT) are a common cause of chronic kidney disease in children. Most patients will reach end-stage renal function and dialysis or transplantation in childhood or early adulthood. Patients with CAKUT deserve a careful evaluation before a kidney transplant; detailed imaging and functional studies are necessary, particularly in the presence of lower urinary tract abnormalities, and surgical procedures are advisable in selected cases. A higher incidence of complications has been reported after a kidney transplant in CAKUT, mainly urinary tract infections. However, in the long term, the prognosis seems to be comparable to other kidney diseases. A large number of reports are available in the literature on medical and surgical management of patients with CAKUT before, during, and after a kidney transplant; almost all recommendations of surgical procedures before a kidney transplantation are based on retrospective not controlled studies or personal opinions; prospective controlled studies are needed. In this narrative, nonsystematic review, we report the results of recently published selected studies and underline questions that should be addressed in future guidelines.https://www.mdpi.com/2227-9059/13/4/932congenital abnormalities of the kidney and urinary tract (CAKUT)chronic kidney disease (CKD)kidney transplantation (KTx) |
| spellingShingle | Silvio Maringhini Lars Pape Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT) Biomedicines congenital abnormalities of the kidney and urinary tract (CAKUT) chronic kidney disease (CKD) kidney transplantation (KTx) |
| title | Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT) |
| title_full | Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT) |
| title_fullStr | Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT) |
| title_full_unstemmed | Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT) |
| title_short | Kidney Transplantation in Congenital Abnormalities of Kidney and Urinary Tract (CAKUT) |
| title_sort | kidney transplantation in congenital abnormalities of kidney and urinary tract cakut |
| topic | congenital abnormalities of the kidney and urinary tract (CAKUT) chronic kidney disease (CKD) kidney transplantation (KTx) |
| url | https://www.mdpi.com/2227-9059/13/4/932 |
| work_keys_str_mv | AT silviomaringhini kidneytransplantationincongenitalabnormalitiesofkidneyandurinarytractcakut AT larspape kidneytransplantationincongenitalabnormalitiesofkidneyandurinarytractcakut |